Since their introduction in the late 2000s, anti-vascular endothelial growth factor (VEGF) agents have become the first-line choice for center-involved diabetic macular edema (DME). Even with its proven effectiveness, there are still cases that do not respond satisfactorily. In those cases, a treatment option is to change to another anti-VEGF drug. In this paper, the authors review studies on switching between different anti-VEGF drugs in the treatment of persistent DME. An extensive bibliographic review was done using PubMed, Embase, and Scopus. Fourteen studies published from March 2010 to April 2017 reporting switching from anti-VEGF drugs in DME treatment were included. All reported good anatomical results after conversion; however, visual acuity outcomes showed great variability between publications. Therefore, switching to other anti-VEGFs in patients with DME not responding to previous anti-VEGF therapy may be an option, but the results are still not well-known due to a lack of randomized clinical trials.
机构:
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 7101 Fairway Dr, Palm Beach Gardens, 33418, FLDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 7101 Fairway Dr, Palm Beach Gardens, 33418, FL
Vaziri K.
Fortun J.A.
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Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 7101 Fairway Dr, Palm Beach Gardens, 33418, FLDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 7101 Fairway Dr, Palm Beach Gardens, 33418, FL
机构:
Department of Ophthalmology, Wuhan School of Clinical Medicine, Southern Medical University (Wuhan General Hospital of Guangzhou Military Region)Department of Ophthalmology, Wuhan School of Clinical Medicine, Southern Medical University (Wuhan General Hospital of Guangzhou Military Region)
Xiao-Li Huang
Yan-Ping Song
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Department of Ophthalmology, Wuhan School of Clinical Medicine, Southern Medical University (Wuhan General Hospital of Guangzhou Military Region)Department of Ophthalmology, Wuhan School of Clinical Medicine, Southern Medical University (Wuhan General Hospital of Guangzhou Military Region)
Yan-Ping Song
Qin Ding
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Department of Ophthalmology, Wuhan School of Clinical Medicine, Southern Medical University (Wuhan General Hospital of Guangzhou Military Region)Department of Ophthalmology, Wuhan School of Clinical Medicine, Southern Medical University (Wuhan General Hospital of Guangzhou Military Region)
Qin Ding
Xiao Chen
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Department of Ophthalmology, Wuhan School of Clinical Medicine, Southern Medical University (Wuhan General Hospital of Guangzhou Military Region)Department of Ophthalmology, Wuhan School of Clinical Medicine, Southern Medical University (Wuhan General Hospital of Guangzhou Military Region)
Xiao Chen
Ling Hong
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Department of Ophthalmology, Wuhan School of Clinical Medicine, Southern Medical University (Wuhan General Hospital of Guangzhou Military Region)Department of Ophthalmology, Wuhan School of Clinical Medicine, Southern Medical University (Wuhan General Hospital of Guangzhou Military Region)
机构:
Southern Med Univ, Wuhan Sch Clin Med, Dept Ophthalmol, Wuhan Gen Hosp Guangzhou Mil Reg, 627 Wu Luo Rd, Wuhan 430060, Hubei, Peoples R ChinaSouthern Med Univ, Wuhan Sch Clin Med, Dept Ophthalmol, Wuhan Gen Hosp Guangzhou Mil Reg, 627 Wu Luo Rd, Wuhan 430060, Hubei, Peoples R China
Huang, Xiao-Li
Song, Yan-Ping
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Southern Med Univ, Wuhan Sch Clin Med, Dept Ophthalmol, Wuhan Gen Hosp Guangzhou Mil Reg, 627 Wu Luo Rd, Wuhan 430060, Hubei, Peoples R ChinaSouthern Med Univ, Wuhan Sch Clin Med, Dept Ophthalmol, Wuhan Gen Hosp Guangzhou Mil Reg, 627 Wu Luo Rd, Wuhan 430060, Hubei, Peoples R China
Song, Yan-Ping
Ding, Qin
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Southern Med Univ, Wuhan Sch Clin Med, Dept Ophthalmol, Wuhan Gen Hosp Guangzhou Mil Reg, 627 Wu Luo Rd, Wuhan 430060, Hubei, Peoples R ChinaSouthern Med Univ, Wuhan Sch Clin Med, Dept Ophthalmol, Wuhan Gen Hosp Guangzhou Mil Reg, 627 Wu Luo Rd, Wuhan 430060, Hubei, Peoples R China
Ding, Qin
Chen, Xiao
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Southern Med Univ, Wuhan Sch Clin Med, Dept Ophthalmol, Wuhan Gen Hosp Guangzhou Mil Reg, 627 Wu Luo Rd, Wuhan 430060, Hubei, Peoples R ChinaSouthern Med Univ, Wuhan Sch Clin Med, Dept Ophthalmol, Wuhan Gen Hosp Guangzhou Mil Reg, 627 Wu Luo Rd, Wuhan 430060, Hubei, Peoples R China
Chen, Xiao
Hong, Ling
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Southern Med Univ, Wuhan Sch Clin Med, Dept Ophthalmol, Wuhan Gen Hosp Guangzhou Mil Reg, 627 Wu Luo Rd, Wuhan 430060, Hubei, Peoples R ChinaSouthern Med Univ, Wuhan Sch Clin Med, Dept Ophthalmol, Wuhan Gen Hosp Guangzhou Mil Reg, 627 Wu Luo Rd, Wuhan 430060, Hubei, Peoples R China