Transition metal-free protodecarboxylation of electron rich aromatic acids under mild conditions

被引：10

作者：

Fang, Jingxian ^{[1
]}

Wang, Dangui ^{[1
]}

Deng, Guo-Jun ^{[1
]}

Gong, Hang ^{[1
]}

机构：

[1] Xiangtan Univ, Coll Chem, Minist Educ, Key Lab Environm Friendly Chem & Applicat, Xiangtan 413305, Peoples R China

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 48期

基金：

中国国家自然科学基金;

关键词：

Decarboxylation; Metal-free; Aromatic acid; Halogenation; (HETERO)AROMATIC CARBOXYLIC-ACIDS; CROSS-COUPLING REACTION; C-H ARYLATION; BENZOIC-ACIDS; CATALYZED PROTODECARBOXYLATION; BIARYL SYNTHESIS; POTASSIUM POLYFLUOROBENZOATES; DECARBOXYLATIVE PALLADATION; OXIDATIVE DECARBOXYLATION; FACILE DECARBOXYLATION;

D O I：

10.1016/j.tetlet.2017.10.036

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and practical method for the transition metal-free protodecarboxylation of aromatic acids using readily available and safe sodium persulfate as initiator was described. This environment-friendly decarboxylation approach was performed at 60 degrees C in ethanol and could easily scale up to the gram level with a good yield. In Particular, the tandem reactions of decarboxylation and halogenation were achieved by the addition of the corresponding halogenating reagents to the reaction system. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：4503 / 4506

页数：4

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