New Approaches to Drug-DNA Interactions Based on Graphical Representation and Numerical Characterization of DNA Sequences

被引：0

作者：

Nandy, Ashesh ^{[2
]}

Basak, Subhash C. ^{[1
]}

机构：

[1] Univ Minnesota, Nat Resources Res Inst, Duluth, MN 55811 USA

[2] Jadavpur Univ, Sch Environm Sci, Kolkata 700032, India

来源：

CURRENT COMPUTER-AIDED DRUG DESIGN | 2010年 / 6卷 / 04期

关键词：

Numerical characterization; Graphical representation; base distribution characteristics; DNA sequence; drug design; drug-DNA interface; chemical toxicity; toxicity indexes; TOPOLOGICAL INDEXES; PROTEIN SEQUENCES; BINDING; BIODESCRIPTORS; DESCRIPTORS; SIMILARITY; PREDICTION; PROTEOMICS; DISCOVERY;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Graphical representations of DNA sequences is a new field of analysis of the DNA and RNA sequences that have the potential to be of utility in determination of drug-DNA interaction sites and also yield indexation schemes to quantify levels of potency or toxicity of various chemicals and drugs. In this paper we explain the new techniques of analysis and briefly review some of the applications that have been made relevant to the field of drug design and chemical toxicity measures specifically in relation to DNA and RNA sequences. The review concludes with some remarks on the future directions that could be taken in development and applications of this nascent technique.

引用

页码：283 / 289

页数：7

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