Cancer chemopreventive agents, serratane-type triterpenoids from Picea jezoensis

被引：41
|
作者：
Tanaka, R
Minami, T
Tsujimoto, K
Matsunaga, S
Tokuda, H
Nishino, H
Terada, Y
Yoshitake, A
机构：
[1] Osaka Univ Pharmaceut Sci, Dept Med Chem, Takatsuki, Osaka 5691094, Japan
[2] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan
[3] Meijo Univ, Fac Pharmaceut Sci, Tenpaku Ku, Nagoya, Aichi 4688503, Japan
来源：
CANCER LETTERS | 2001年 / 172卷 / 02期
关键词：
Picea Jezoensis (Sieb. et Zucc.) Carr. Jezoensis; Picea Jezoensis (Sieb. et Zucc.) Carr. Hondoensis (Mayer); Pinaceae; anti-tumor promoter; Epstein-Barr virus; two stage carcinogenesis; 13; alpha; 14; alpha-epoxy-3; beta-methoxyserratan-21; beta-ol; serratane; triterpenoid;
D O I：
10.1016/S0304-3835(01)00650-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Seven serratane-type triterpenoids isolated from the cuticle of Picea jezoensis (Sieb. et Zucc.) Carr. jezoensis (Pinaceae) and the stein bark of Picea jezoensis (Sieb. et Zucc.) Carr. hondoensis (Mayer) Rehder (Pinaceae) were studied their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). All compounds showed strong inhibitory effects on the EBV-EA activation, being stronger than that of oleanolic acid, which exerts on cancer preventive activity in animal carcinogenesis models. Among these compounds, 13 alpha, 14 alpha -epoxy-3 beta -methoxyserratan-21 beta P-ol and 3 beta -methoxy-21 alpha -hydroxyscrrat-14-en-29-al were investigated for the inhibitory effects in a two-stage mouse skin carcinogenesis test on mouse skin using 7,12-dimethylbenz[a]anthracene as initiator and TPA as promoter. 13 alpha ,14 alpha -Epoxy-3 beta -methoxyserratan-21 beta -ol was found to exhibit the excellent anti-tumor promoting activity in the in vivo carcinogenesis test. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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页码：119 / 126
页数：8
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