Numerical validation of a synthetic cell-based model of blood coagulation

被引：3

作者：

Pavlova, J. ^{[1
]}

Fasano, A. ^{[2
,3
,4
]}

Janela, J. ^{[5
,6
]}

Sequeira, A. ^{[1
,5
]}

机构：

[1] Univ Lisbon, CEMAT, IST, P-1699 Lisbon, Portugal

[2] Univ Florence, U Dini, Dipartimento Matemat, I-50121 Florence, Italy

[3] FIAB SpA, Florence, Italy

[4] CNR, Ist Anal Sistemi & Informat IASI Antonio Ruberti, I-00185 Rome, Italy

[5] Univ Lisbon, Dept Maternat, P-1699 Lisbon, Portugal

[6] Univ Lisbon, CEMAPRE, ISEG, P-1699 Lisbon, Portugal

来源：

JOURNAL OF THEORETICAL BIOLOGY | 2015年 / 380卷

关键词：

Blood coagulation; Platelets; Biochemical reactions; Mathematical modeling; Slip boundary conditions; Reaction-advection-diffusion equations; OPERATOR; SIMULATION; DYNAMICS;

D O I：

10.1016/j.jtbi.2015.06.004

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In Fasano et al. (2012) a new reduced mathematical model for blood coagulation was proposed, incorporating biochemical and mechanical actions of blood flow and including platelets activity. The model was characterized by a considerable simplification of the differential system associated to the biochemical network and it incorporated the role of blood slip at the vessel wall as an extra source of activated platelets. The purpose of this work is to check the validity of the reduced mathematical model, using as a benchmark the model presented in Anand et al. (2008), and to investigate the importance of the blood slip velocity in the blood coagulation process. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：367 / 379

页数：13

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