SAFETY, TOLERABILITY AND PHARMACOKINETICS OF EVINACUMAB, AN ANGIOPOIETIN-LIKE PROTEIN 3 (ANGPTL3) INHIBITOR, IN HEALTHY JAPANESE AND CAUCASIAN SUBJECTS

被引:0
|
作者
Harada-Shiba, M. [1 ]
Ali, S. [2 ]
Gipe, D. A. [2 ]
Gasparino, E. [3 ]
Son, V. [4 ]
Pordy, R. [2 ]
Catapano, A. L. [5 ]
机构
[1] Natl Cerebral & Cardiovasc Ctr, Mol Innovat Lipidol, Suita, Osaka, Japan
[2] Regeneron Pharmaceut Inc, Cardiovasc & Metab Therapeut, New York, NY USA
[3] Regeneron Pharmaceut Inc, Therapeut Area Program Management, New York, NY USA
[4] Regeneron Pharmaceut Inc, Biostat & Data Management, New York, NY USA
[5] IRCCS MultiMed, Irccs Multimed Sesto S Giovanni, Milan, Italy
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1333
引用
收藏
页码:E36 / E37
页数:2
相关论文
共 50 条
  • [41] Pharmacokinetics, safety and tolerability of rotigotine after trandermal patch administration in Japanese and Caucasian healthy subjects
    Cawello, W.
    Braun, M.
    Horstmann, R.
    Funaki, T.
    Tadayasu, Y.
    [J]. MOVEMENT DISORDERS, 2006, 21 : S547 - S548
  • [42] ANGPTL3 (Angiopoietin-Like 3) Preferentially Resides on High-Density Lipoprotein in the Human Circulation, Affecting Its Activity
    Kraaijenhof, Jordan M.
    Tromp, Tycho R.
    Nurmohamed, Nick S.
    Reeskamp, Laurens F.
    Langenkamp, Marije
    Levels, Johannes H. M.
    Boekholdt, S. Matthijs
    Wareham, Nicholas J.
    Hoekstra, Menno
    Stroes, Erik S. G.
    Hovingh, G. Kees
    Grefhorst, Aldo
    [J]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2023, 12 (21):
  • [43] Pharmacokinetics, Tolerability, and Safety of Single and Multiple Omecamtiv Mecarbil Doses in Healthy Japanese and Caucasian Subjects
    Ashit Trivedi
    Fady I. Malik
    Mia Mackowski
    Shauna Hutton
    Makoto Aoki
    Siddique Abbasi
    Sandeep Dutta
    Edward Lee
    [J]. European Journal of Drug Metabolism and Pharmacokinetics, 2021, 46 : 759 - 770
  • [44] PHARMACOKINETICS, TOLERABILITY, AND SAFETY OF THE DUAL ENDOTHELIN RECEPTOR ANTAGONIST MACITENTAN IN JAPANESE AND CAUCASIAN HEALTHY SUBJECTS
    Bruderer, S.
    Marjason, J.
    Sidharta, P.
    Dingemanse, J.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2011, 89 : S83 - S83
  • [45] Pharmacokinetics, Tolerability, and Safety of Single and Multiple Omecamtiv Mecarbil Doses in Healthy Japanese and Caucasian Subjects
    Trivedi, Ashit
    Malik, Fady, I
    Mackowski, Mia
    Hutton, Shauna
    Aoki, Makoto
    Abbasi, Siddique
    Dutta, Sandeep
    Lee, Edward
    [J]. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2021, 46 (06) : 759 - 770
  • [46] Association between plasma angiopoietin-like protein 3 and arterial wall thickness in healthy subjects
    Hatsuda, Sawako
    Shoji, Tetsuo
    Shinohara, Kayo
    Kimoto, Eiji
    Mori, Katsuhito
    Fukumoto, Shinya
    Koyama, Hidenori
    Emoto, Masanori
    Nishizawa, Yoshiki
    [J]. JOURNAL OF VASCULAR RESEARCH, 2007, 44 (01) : 61 - 66
  • [47] Circulating angiopoietin-like protein 8 (ANGPTL8) and ANGPTL3 concentrations in relation to anthropometric and metabolic profiles in Korean children: a prospective cohort study
    Hye Soo Chung
    Min Jung Lee
    Soon Young Hwang
    Hyun Jung Lee
    Hye Jin Yoo
    Ji-A Seo
    Sin Gon Kim
    Nan Hee Kim
    Sei Hyun Baik
    Dong Seop Choi
    Seon Mi Kim
    Kyung Mook Choi
    [J]. Cardiovascular Diabetology, 15
  • [48] Circulating angiopoietin-like protein 8 (ANGPTL8) and ANGPTL3 concentrations in relation to anthropometric and metabolic profiles in Korean children: a prospective cohort study
    Chung, Hye Soo
    Lee, Min Jung
    Hwang, Soon Young
    Lee, Hyun Jung
    Yoo, Hye Jin
    Seo, Ji-A
    Kim, Sin Gon
    Kim, Nan Hee
    Baik, Sei Hyun
    Choi, Dong Seop
    Kim, Seon Mi
    Choi, Kyung Mook
    [J]. CARDIOVASCULAR DIABETOLOGY, 2016, 15
  • [49] Pharmacokinetics and Safety Of Idelalisib, a Novel PI3Kδ Inhibitor, In Japanese and Caucasian Subjects
    Jin, Feng
    Robeson, Michelle
    Zhou, Huafeng
    Moyer, Candra
    Ramanathan, Srini
    [J]. BLOOD, 2013, 122 (21)
  • [50] Pharmacokinetics and safety of idelalisib, a novel PI3Kδ inhibitor, in Japanese and Caucasian subjects
    Jin, Feng
    Robeson, Michelle
    Zhou, Huafeng
    Moyer, Candra
    Ramanathan, Srini
    [J]. CANCER RESEARCH, 2014, 74 (19)