Rapid, High Resolution Screening of Biomaterial Hydrogelators by μ2Rheology

被引：19
|
作者：
Schultz, Kelly M. [1 ,2 ]
Bayles, Alexandra V. [1 ,2 ]
Baldwin, Aaron D. [3 ,4 ]
Kiick, Kristi L. [3 ,4 ]
Furst, Eric M. [1 ,2 ]
机构：
[1] Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA
[2] Univ Delaware, Ctr Mol & Engn Thermodynam, Newark, DE 19716 USA
[3] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA
[4] Univ Delaware, Delaware Biotechnol Inst, Newark, DE 19716 USA
来源：
BIOMACROMOLECULES | 2011年 / 12卷 / 12期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
MOLECULAR-SIZE DISTRIBUTION; 3-DIMENSIONAL POLYMERS; PEG HYDROGELS; MICRORHEOLOGY; COMPONENTS; RHEOLOGY; GELATION; PEPTIDE; SYSTEM;
D O I：
10.1021/bm201214r
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A combination of sample manipulation and rheological characterization at the microscale is used to identify the gelation of poly(ethylene glycol)-heparin hydrogels over a wide range of compositions. A microfluidic device produces 50-100 droplet samples, each with a different composition. Multiple particle tracking microrheology is used to measure the rheological state of each sample. This combination requires little material and enables efficient and rapid screening of gelation conditions. The high resolution data identifies the gelation reaction percolation boundaries and a lower limit of the total hydrogelator concentration for gelation to occur, which can be used for the subsequent engineering, testing, and processing of these materials.
引用
收藏
页码：4178 / 4182
页数：5
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