NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy

被引：162
|
作者：
Hayakawa, Y
Screpanti, V
Yagita, H
Grandien, A
Ljunggren, HG
Smyth, MJ
Chambers, BJ [1 ]
机构：
[1] Huddinge Univ Hosp, Karolinska Inst, Dept Med, Ctr Infect Med, S-14186 Huddinge, Sweden
[2] Peter MacCallum Canc Ctr, Canc Immunol Program, Melbourne, Vic, Australia
[3] Juntendo Univ, Sch Med, Dept Immunol, Bunkyo Ku, Tokyo 113, Japan
[4] Karolinska Inst, Ctr Microbiol & Tumor Biol, Stockholm, Sweden
来源：
JOURNAL OF IMMUNOLOGY | 2004年 / 172卷 / 01期
关键词：
D O I：
10.4049/jimmunol.172.1.123
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent studies have implicated a possible role for NK cells in regulating dendritic cells (DC) in vitro. In the present study, we demonstrate that immature DC are rapidly eliminated by NK cells in vivo via a pathway dependent on the TNF-related apoptosis-inducing ligand (TRAIL). Elimination of NK cells and/or neutralization of TRAIL function during immunization with immature DC loaded with nonself or tumor Ags significantly enhanced T cell responses to these Ags and Ag-specific tumor immunity. These data suggested that NK cell TRAIL might regulate responses to vaccination by controlling the survival of Ag-loaded DC.
引用
收藏
页码：123 / 129
页数：7
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