Improved linkage map and thirty new microsatellite markers for rat Chromosome 10

被引：3
|
作者：
Dukhanina, OI
Sverdlov, VE
Hoebee, B
Rapp, JP
机构：
[1] Med Coll Ohio, Dept Physiol & Mol Med, Toledo, OH 43614 USA
[2] Natl Inst Publ Hlth & Environm, Hlth Effects Res Lab, NL-3720 BA Bilthoven, Netherlands
来源：
MAMMALIAN GENOME | 1999年 / 10卷 / 01期
关键词：
D O I：
10.1007/s003359900936
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An improved linkage map for rat Chromosome (Chr) 10 with two F-2 populations was constructed. Thirty new microsatellite markers were generated from a Chr 10-specific, small-insert genomic library and mapped to rat Chr 10. Among them were the rat homologs for the mouse gene for light and heavy chains of myeloperoxidase and human neurofibromatosis 1. Eight newly generated markers (D10Mco62, D10Mco63, D10Mco64, D10Mco65, D10Mco67, D10Mco68, D10Mco70, and D10Mco74) were mapped to the region of the rat Chr 10 blood pressure QTL. The availability of such markers may be instrumental in the search for genes responsible for the hypertension.
引用
收藏
页码：26 / 29
页数：4
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