Wound healing potential of the ethanolic extracts of Bidens pilosa and Ocimum suave

被引:0
|
作者
Hassan, Kyakulaga A. [2 ,3 ]
Deogratius, Olila [3 ]
Nyafuono, Jane F. [1 ]
Francis, Omujal [1 ]
Engeu, Ogwang P. [1 ]
机构
[1] Minist Hlth Uganda, Nat Chemotherapeut Res Inst, Kampala, Uganda
[2] Makerere Univ, Coll Hlth Sci, Dept Pharmacol & Therapeut, Kampala, Uganda
[3] Makerere Univ, Fac Vet Med, Div Pharmacol, Dept Physiol Sci, Kampala, Uganda
来源
AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY | 2011年 / 5卷 / 02期
关键词
Bidens pilosa; Ocimum suave; wound healing; epithelialization; ethanolic extract; ANTIOXIDANT;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The ethanolic extracts of Bidens pilosa and Ocimum suave were evaluated for their wound healing potential on excision wound models in Wistar albino rats. A total of nine (n=9) rats per group were used to assess the wound healing potential of the extracts. There were four groups of animals treated topically twice a day with either of the following: O. suave, B. pilosa, neomycin sulfate or distilled water. The rate of wound contraction, epithelialization, and complete healing were assessed over the experimental period. Wounds treated with extracts of O. suave, B. pilosa and neomycin sulfate had faster rates of wound contraction (p<0.05) on days 3, 6 and 9 than negative control. Histological examination of wound on day 7 also revealed better collagenation, angiogenesis and organization of the wound tissue. Epithelialisation and total healing time for B. pilosa and O. suave were comparable to neomycin sulfate (p>0.05). In conclusion, extracts of O. suave and B. pilosa show potential for use as alternative to neomycin for treatment of wounds.
引用
收藏
页码:132 / 136
页数:5
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