From role of gut microbiota to microbial-based therapies in type 2-diabetes

被引：61
|
作者：
Leylabadlo, Hamed Ebrahimzadeh [1 ,2 ,3 ]
Sanaie, Sarvin [2 ,4 ]
Heravi, Fatemah Sadeghpour [5 ]
Ahmadian, Zainab [6 ]
Ghotaslou, Reza [1 ,3 ]
机构：
[1] Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran
[3] Tabriz Univ Med Sci, Fac Med, Dept Bacteriol & Virol, Tabriz, Iran
[4] Tabriz Univ Med Sci, Aging Res Inst, Tabriz, Iran
[5] Macquarie Univ, Fac Med & Hlth Sci, Surg Infect Res Grp, Sydney, NSW 2019, Australia
[6] Zanjan Univ Med Sci, Sch Pharm, Dept Pharmaceut, Zanjan 45139561821, Iran
来源：
INFECTION GENETICS AND EVOLUTION | 2020年 / 81卷
关键词：
Microbiota; Microbiome; Prebiotics; Probiotics; Type; 2; diabetes; TRIMETHYLAMINE-N-OXIDE; GLUCAGON-LIKE PEPTIDE-1; IMPAIRED GLUCOSE-TOLERANCE; INULIN-TYPE FRUCTANS; CHAIN AMINO-ACIDS; DIABETES-MELLITUS; LIPID PROFILE; DOUBLE-BLIND; INTESTINAL MICROBIOTA; METABOLIC ENDOTOXEMIA;
D O I：
10.1016/j.meegid.2020.104268
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The incidence of type 2 diabetes mellitus (T2DM) has increased dramatically at an alarming level around the world.T2DM is associated with changeable risk factors in lifestyle as well as genetic and family associated risk factors. More importantly, imbalanced or impaired gut microbial distribution (dysbiosis) has been reported as a contributing risk factor in insulin resistance progression in T2DM. Dysbiosis may restructure the metabolic and functional pathways in the intestine which are involved in the development of T2DM. However, several studies have indicated the constructive and helpful effect of prebiotics, probiotics, and fecal microbiota transplantation (FMT) on the improvement of gut microbiota (GM) and accordingly host metabolism. In this review, the association between GM and T2DM have been evaluated and the role of prebiotics, probiotics and FMT, as potential therapeutic approaches have been discussed. Relevant studies were obtained randomly from online databases such as PubMed/Medline and ISI Web of Science.
引用
收藏
页数：12
相关论文
共 50 条
  • [31] Role of Immune Cells in Mediating the Causal Effect of Gut Microbiota on Type 2 Diabetes
    Liu, Ruifang
    Chai, Ruiting
    Yang, Zhaoyang
    Li, Candong
    CURRENT MOLECULAR MEDICINE, 2025,
  • [32] Gut Microbiota in the Progression of Type 2 Diabetes and the Potential Role of Exercise: A Critical Review
    Deli, Chariklia K.
    Fatouros, Ioannis G.
    Poulios, Athanasios
    Liakou, Christina A.
    Draganidis, Dimitrios
    Papanikolaou, Konstantinos
    Rosvoglou, Anastasia
    Gatsas, Athanasios
    Georgakouli, Kalliopi
    Tsimeas, Panagiotis
    Jamurtas, Athanasios Z.
    LIFE-BASEL, 2024, 14 (08):
  • [33] Effects of gut microbial-based treatments on gut microbiota, behavioral symptoms, and gastrointestinal symptoms in children with autism spectrum disorder: A systematic review
    Yang, Jiaxin
    Fu, Xi
    Liao, Xiaoli
    Li, Yamin
    PSYCHIATRY RESEARCH, 2020, 293
  • [34] The Dual Specificity Role of Transcription Factor FOXO in Type 2-diabetes and Cancer
    Fatima, Kaneez
    Mathew, Shilu
    Faheem, Muhammed
    Mehmood, Tahir
    Yassine, Hadi Mohamad
    Al Thani, Asmaa A.
    Abdel-Hafiz, Hany
    Al Ghamdy, Khalid
    Qadri, Ishtiaq
    CURRENT PHARMACEUTICAL DESIGN, 2018, 24 (24) : 2839 - 2848
  • [35] The challenges of cardiovascular protection for type 2-diabetes
    不详
    HERZ, 2007, 32 (05) : B9 - B10
  • [36] The Gut Microbial Endocrine Organ in Type 2 Diabetes
    Massey, William
    Brown, J. Mark
    ENDOCRINOLOGY, 2021, 162 (02)
  • [37] The gut microbiota and Type 1 Diabetes
    Guelden, Elke
    Wong, F. Susan
    Wen, Li
    CLINICAL IMMUNOLOGY, 2015, 159 (02) : 143 - 153
  • [38] Gut Microbiota and Type 1 Diabetes
    Han, Hui
    Li, Yuying
    Fang, Jun
    Liu, Gang
    Yin, Jie
    Li, Tiejun
    Yin, Yulong
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (04)
  • [39] The role of bacterial lipopolysaccharides and gut microbiota dysbiosis in type 1 diabetes
    Silojarvi, Satu
    Leino, Linda
    Poysti, Sakari
    Hanninen, Arno
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2024, 54 : 971 - 971
  • [40] Early Nutrition and Risk of Type 1 Diabetes: The Role of Gut Microbiota
    Verduci, Elvira
    Mameli, Chiara
    Amatruda, Matilde
    Petitti, Agnese
    Vizzuso, Sara
    El Assadi, Farah
    Zuccotti, Gianvincenzo
    Alabduljabbar, Shaikha
    Terranegra, Annalisa
    FRONTIERS IN NUTRITION, 2020, 7
12345