TGF-β1 attenuated branching morphogenesis of embryonic murine submandibular gland through Smad3 activation

被引：1
|
作者：
Gao, P. [1 ,2 ]
Qiao, X. -H. [1 ,2 ]
Gou, L. -M. [1 ,2 ]
Huang, Y. [3 ]
Li, Q. -H. [4 ]
Li, L. -J. [1 ,2 ]
Wang, X. -Y. [1 ,2 ]
Li, C. -J. [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp Stomatol, Dept Head & Neck Oncol, Chengdu, Sichuan, Peoples R China
[3] Univ Elect Sci & Technol, Sichuan Prov Hosp, Dept Oral & Maxillofacial Surg, Chengdu, Sichuan, Peoples R China
[4] Chinese & Western Med Hosp Panzhihua, Panzhihua, Peoples R China
来源：
ANATOMIA HISTOLOGIA EMBRYOLOGIA | 2017年 / 46卷 / 06期
基金：
中国国家自然科学基金;
关键词：
TGF-BETA; GROWTH;
D O I：
10.1111/ahe.12295
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Transforming growth factor-beta 1 (TGF-beta 1) plays several crucial regulatory roles in multiple physiological and pathological processes. The aim of this work was to investigate the role of TGF-beta 1 in branching morphogenesis of salivary gland. We harvested and cultured submandibular salivary glands (SMGs) from murine embryos, which were then treated with exogenous TGF-beta 1, or its neutralized antibody, Smad3 inhibitor, or Smad3 small interfering RNA (siRNA). Our results suggested that TGF-beta 1 attenuated branching morphogenesis of embryonic murine SMG via Smad3 activation, thus playing a negative regulatory role in salivary gland development.
引用
收藏
页码：600 / 605
页数：6
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