3-Acylindoles Synthesis: Ruthenium-Catalyzed Carbonylative Coupling of Indoles and Aryl Iodides

被引：16
|
作者：
Wang, Zechao [1 ]
Yin, Zhiping [1 ]
Wu, Xiao-Feng [1 ]
机构：
[1] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 17期
关键词：
C-H BOND; FRIEDEL-CRAFTS ACYLATION; DIRECT ARYLATION; REGIOSELECTIVE ACYLATION; CARBON-MONOXIDE; GENERAL-METHOD; BENZENE-RING; FUNCTIONALIZATION; ACTIVATION; HETEROCYCLES;
D O I：
10.1021/acs.orglett.7b02320
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and convenient procedure for the synthesis of 3-acylindoles from simple indoles and aryl iodides has been established. Through ruthenium-catalyzed carbonylative C-H functionalization of indoles, with Mo(CO)(6) as the solid CO source, the desired indol-3-yl aryl ketones were isolated in moderate to good yields. Not only N-alkylindoles but also N-H indoles can be applied here.
引用
收藏
页码：4680 / 4683
页数：4
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