The DNA Methylation Maintenance Protein UHRF1 Regulates Fetal Globin Expression Independent of HBG Promoter DNA Methylation

被引:0
|
作者
Feng, Ruopeng [1 ]
Doerfler, Phillip A. [1 ]
Yao, Yu [1 ]
Tang, Xing [1 ]
Wang, Yong-Dong [2 ]
Li, Chunliang [3 ]
Root, David E. [4 ]
Cheng, Yong [1 ]
Weiss, Mitchell J. [1 ]
机构
[1] St Jude Childrens Res Hosp, Dept Hematol, 332 N Lauderdale St, Memphis, TN 38105 USA
[2] St Jude Childrens Res Hosp, Dept Computat Biol, 332 N Lauderdale St, Memphis, TN 38105 USA
[3] St Jude Childrens Res Hosp, Dept Tumor Cell Biol, 332 N Lauderdale St, Memphis, TN 38105 USA
[4] Broad Inst MIT & Harvard, Genet Perturbat Platform, Cambridge, MA USA
关键词
D O I
10.1182/blood-2018-99-115589
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
410
引用
收藏
页数:2
相关论文
共 50 条
  • [11] Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation
    Scott B Rothbart
    Krzysztof Krajewski
    Nataliya Nady
    Wolfram Tempel
    Sheng Xue
    Aimee I Badeaux
    Dalia Barsyte-Lovejoy
    Jorge Y Martinez
    Mark T Bedford
    Stephen M Fuchs
    Cheryl H Arrowsmith
    Brian D Strahl
    Nature Structural & Molecular Biology, 2012, 19 : 1155 - 1160
  • [12] Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation
    Rothbart, Scott B.
    Krajewski, Krzysztof
    Nady, Nataliya
    Tempel, Wolfram
    Xue, Sheng
    Badeaux, Aimee I.
    Barsyte-Lovejoy, Dalia
    Martinez, Jorge Y.
    Bedford, Mark T.
    Fuchs, Stephen M.
    Arrowsmith, Cheryl H.
    Strahl, Brian D.
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2012, 19 (11) : 1155 - +
  • [13] Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for DNA methylation maintenance
    Rothbart, Scott B.
    Dickson, Bradley M.
    Ong, Michelle S.
    Krajewski, Krzysztof
    Houliston, Scott
    Kireev, Dmitri B.
    Arrowsmith, Cheryl H.
    Strahl, Brian D.
    CANCER RESEARCH, 2013, 73
  • [14] Promoter methylation-independent reactivation of PAX1 by curcumin and resveratrol is mediated by UHRF1
    Parashar, Gaurav
    Capalash, Neena
    CLINICAL AND EXPERIMENTAL MEDICINE, 2016, 16 (03) : 471 - 478
  • [15] S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance
    Jiqin Zhang
    Qinqin Gao
    Pishun Li
    Xiaoli Liu
    Yuanhui Jia
    Weicheng Wu
    Jiwen Li
    Shuo Dong
    Haruhiko Koseki
    Jiemin Wong
    Cell Research, 2011, 21 : 1723 - 1739
  • [16] High-resolution Epigenome Mapping Reveals Distinct and Divergent Roles for UHRF1 in the Maintenance of DNA Methylation
    Tiedemann, Rochelle
    Du, Qian
    Dickson, Bradley
    Kong, Xiangqian
    Chomiak, Alison
    Zhou, Wanding
    Johnson, Benjamin
    Baylin, Stephen
    Jones, Peter
    Clark, Susan
    Rothbart, Scott
    FASEB JOURNAL, 2020, 34
  • [17] Promoter methylation-independent reactivation of PAX1 by curcumin and resveratrol is mediated by UHRF1
    Gaurav Parashar
    Neena Capalash
    Clinical and Experimental Medicine, 2016, 16 : 471 - 478
  • [18] The Growing Complexity of UHRF1-Mediated Maintenance DNA Methylation
    Xie, Si
    Qian, Chengmin
    GENES, 2018, 9 (12):
  • [19] DNA Methylation and Globin Gene Expression
    Saunthararajah, Yogenthiran
    Lavelle, Donald
    BLOOD, 2008, 112 (11) : 1347 - 1348
  • [20] S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance
    Zhang, Jiqin
    Gao, Qinqin
    Li, Pishun
    Liu, Xiaoli
    Jia, Yuanhui
    Wu, Weicheng
    Li, Jiwen
    Dong, Shuo
    Koseki, Haruhiko
    Wong, Jiemin
    CELL RESEARCH, 2011, 21 (12) : 1723 - 1739