Interferon-γ and cancer immunoediting

被引：112
|
作者：
Dunn, GP [1 ]
Ikeda, H [1 ]
T Bruce, A [1 ]
Koebel, C [1 ]
Uppaluri, R [1 ]
Bui, J [1 ]
Chan, R [1 ]
Diamond, M [1 ]
White, JM [1 ]
Sheehan, KCF [1 ]
Schreiber, RD [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Pathol & Immunol, Ctr Immunol, St Louis, MO 63110 USA
来源：
IMMUNOLOGIC RESEARCH | 2005年 / 32卷 / 1-3期
关键词：
interferon-gamma; cancer; immunosurveillance; signal transduction; cancer immunoediting; lymphocytes;
D O I：
10.1385/IR:32:1-3:231
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Over the last 12 yr, we have shown that interferon-gamma and lymphocytes collaborate to regulate tumor development in mice. Specifically, we found that the immune system not only prevents the growth of primary (carcinogen-induced and spontaneous) and transplanted tumors but also sculpts the immunogenicity of tumors that form. These observations led us to refine the old and controversial "cancer immunosurveillance" hypothesis of Burnet and Thomas into one that we termed cancer immunoediting that better emphasizes the paradoxical host-protective and tumor-sculpting roles of immunity on developing tumors. Our current work focuses on defining the molecular mechanisms that underlie cancer immunoediting and exploring the implications of this process for cancer immunotherapy.
引用
收藏
页码：231 / 245
页数：15
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