UCP2 866 G/A gene (rs659366) polymorphism associated with diabetes type 2 in Turkish population

被引：2
|
作者：
Gozel, Nevzat [1 ]
Dalkilic, Semih
机构：
[1] Firat Univ, Dept Internal Med, Fac Med, TR-2300 Elazig, Turkey
来源：
PROGRESS IN NUTRITION | 2017年 / 19卷 / 04期
关键词：
diabetes mellitus type 2; UCP2; gene; polymorphism; STIMULATED INSULIN-SECRETION; MIDDLE-AGED HUMANS; UNCOUPLING PROTEIN-2; COMMON POLYMORPHISM; MULTIPLE-SCLEROSIS; RISK-FACTOR; PROMOTER; OBESITY; MELLITUS; COMPLICATIONS;
D O I：
10.23751/pn.v19i4.6124
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Type 2 diabetes mellitus (T2DM) is a major health problem in worldwide and uncoupling protein-2 (UCP2) that have a role in the regulation of insulin secretion and emergence of diabetes mellitus. In this study we have investigate whether an association between UCP2 866 G/A polymorphism and T2DM. In this study we have collected peripheral blood samples from 50 type 2 diabetes mellitus patients and 50 healhty control individuals. Genomic DNA was isolated from blood samples and UCP2 866 G/A polymorphism was investigated by polymerase chain reaction restriction fragment lenght polymorphism assay (PCR-RFLP). In our results we have not observed any statistically significant association between UCP2 866 G/A polymorphism and risk of T2DM.
引用
收藏
页码：430 / 435
页数：6
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