Radiation Damage Limits to XPCS Studies of Protein Dynamics

被引：9

作者：

Vodnala, Preeti ^{[1
]}

Karunaratne, Nuwan ^{[1
]}

Bera, Sambhunath ^{[2
]}

Lurio, Laurence ^{[1
]}

Thurston, George M. ^{[3
]}

Karonis, Nick ^{[4
,5
]}

Winans, John ^{[4
]}

Sandy, Alec ^{[6
]}

Narayanan, Suresh ^{[6
]}

Yasui, Linda ^{[7
]}

Gaillard, Elizabeth ^{[8
]}

Karumanchi, Kalyan ^{[8
]}

机构：

[1] Northern Illinois Univ, Dept Phys, De Kalb, IL 60115 USA

[2] Amity Univ UP, Amity Ctr Spintron Mat, Sect 125, Noida 201313, India

[3] Rochester Inst Technol, Sch Phys & Astron, Rochester, NY 14623 USA

[4] Northern Illinois Univ, Dept Comp Sci, De Kalb, IL 60115 USA

[5] Argonne Natl Lab, Math & Comp Sci, Argonne, IL 60495 USA

[6] Argonne Natl Lab, Adv Photon Source, Argonne, IL 60495 USA

[7] Northern Illinois Univ, Dept Biol, De Kalb, IL 60115 USA

[8] Northern Illinois Univ, Dept Chem & Biochem, De Kalb, IL 60115 USA

来源：

PROCEEDINGS OF THE 12TH INTERNATIONAL CONFERENCE ON SYNCHROTRON RADIATION INSTRUMENTATION (SRI2015) | 2016年 / 1741卷

关键词：

SPECTROSCOPY;

D O I：

10.1063/1.4952946

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

The limitations to x-ray photon correlation spectroscopy (XPCS) imposed by radiation damage have been evaluated for suspensions of alpha crystallin. We find that the threshold for radiation damage to the measured protein diffusion rate is significantly lower than the threshold for damage to the protein structure. We provide damage thresholds beyond which the measured diffusion coefficients have been modified using both XPCS and dynamic light scattering (DLS).

引用

页数：4

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