Histone deacetylases in skeletal development and bone mass maintenance

被引:77
|
作者
McGee-Lawrence, Meghan E. [1 ]
Westendorf, Jennifer J. [1 ]
机构
[1] Mayo Clin, Rochester, MN 55905 USA
关键词
Hdac; Osteoblast; Osteoclast; Valproate; Vorinostat; MESENCHYMAL STEM-CELLS; CONTROLS CHONDROCYTE HYPERTROPHY; DECREASES ADIPOCYTE FORMATION; OSTEOBLAST DIFFERENTIATION; IN-VIVO; MINERAL DENSITY; TRICHOSTATIN-A; VALPROIC ACID; OSTEOCLAST FORMATION; ANTIEPILEPTIC DRUGS;
D O I
10.1016/j.gene.2010.12.003
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The skeleton is a multifunctional and regenerative organ. Dynamic activities within the bone microenvironment necessitate and instigate rapid and temporal changes in gene expression within the cells (osteoclasts, osteoblasts, and osteocytes) responsible for skeletal maintenance. Regulation of gene expression is controlled, in part, by histone deacetylases (Hdacs), which are intracellular enzymes that directly affect chromatin structure and transcription factor activity. Key roles for several Hdacs in bone development and biology have been elucidated though in vitro and in vivo models. Recent findings suggest that clinical usage of small molecule Hdac inhibitors for conditions like epilepsy, bipolar disorder, cancer, and a multitude of other ailments may have unintended effects on bone cell populations. Here we review the progress that has been made in the last decade in understanding how Hdacs contribute to bone development and maintenance. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码:1 / 11
页数:11
相关论文
共 50 条
  • [1] HISTONE DEACETYLASES IN BONE DEVELOPMENT AND SKELETAL DISORDERS
    Bradley, Elizabeth W.
    Carpio, Lomeli R.
    van Wijnen, Andre J.
    McGee-Lawrence, Meghan E.
    Westendorf, Jennifer J.
    [J]. PHYSIOLOGICAL REVIEWS, 2015, 95 (04) : 1359 - 1381
  • [2] Role of histone deacetylases in bone development and skeletal disorders
    Wang, Jialiang S.
    Yoon, Sung-Hee
    Wein, Marc N.
    [J]. BONE, 2021, 143
  • [3] Regulation of Osteoclast Differentiation and Skeletal Maintenance by Histone Deacetylases
    Faulkner, Bora
    Astleford, Kristina
    Mansky, Kim C.
    [J]. MOLECULES, 2019, 24 (07)
  • [4] Regulation of Histone Deacetylases by MicroRNAs in Bone
    Shreya, S.
    Malavika, D.
    Priya, V. Raj
    Selvamurugan, N.
    [J]. CURRENT PROTEIN & PEPTIDE SCIENCE, 2019, 20 (04) : 356 - 367
  • [5] Are Histone Deacetylases Part of the Lung Structure Maintenance Program?
    Mizuno, S.
    Yasuo, M.
    Kraskauskas, D.
    Bogaard, H. J.
    Voelkel, N. F.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 179
  • [6] Regulation of kidney development by histone deacetylases
    Stacy L. Rosenberg
    Shaowei Chen
    Nathan McLaughlin
    Samir S. El-Dahr
    [J]. Pediatric Nephrology, 2011, 26 : 1445 - 1452
  • [7] Regulation of kidney development by histone deacetylases
    Rosenberg, Stacy L.
    Chen, Shaowei
    McLaughlin, Nathan
    El-Dahr, Samir S.
    [J]. PEDIATRIC NEPHROLOGY, 2011, 26 (09) : 1445 - 1452
  • [8] The role of histone deacetylases in embryonic development
    Dsilva, Priyanka
    Pai, Padmini
    Shetty, Manasa Gangadhar
    Babitha, Kampa S. S.
    [J]. MOLECULAR REPRODUCTION AND DEVELOPMENT, 2023, 90 (01) : 14 - 26
  • [9] EXERCISE AND CLASS IIa HISTONE DEACETYLASES IN HUMAN SKELETAL MUSCLE
    Hargreaves, Mark
    Fairlie, Erin
    McGee, Sean
    Garnham, Andrew
    [J]. FASEB JOURNAL, 2008, 22
  • [10] Histone deacetylases (HDAC) in physiological and pathological bone remodelling
    Cantley, M. D.
    Zannettino, A. C. W.
    Bartold, P. M.
    Fairlie, D. P.
    Haynes, D. R.
    [J]. BONE, 2017, 95 : 162 - 174