The role of histone deacetylases in embryonic development

被引:4
|
作者
Dsilva, Priyanka [1 ]
Pai, Padmini [2 ]
Shetty, Manasa Gangadhar [2 ]
Babitha, Kampa S. S. [2 ]
机构
[1] Manipal Acad Higher Educ, Manipal Sch Life Sci, Dept Biotechnol, Manipal, Karnataka, India
[2] Manipal Acad Higher Educ, Manipal Sch Life Sci, Dept Biophys, Manipal 576104, Karnataka, India
关键词
cardiogenesis; embryogenesis; HDAC; KDAC inhibitors; HDACs; KDACs; preimplantation embryos; DNA METHYLTRANSFERASE 3B; GENE-EXPRESSION; HDAC ACTIVITY; STEM-CELLS; INHIBITION; GROWTH; ZEBRAFISH; OOCYTES; HISTONE-DEACETYLASE-1; DIFFERENTIATION;
D O I
10.1002/mrd.23659
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The basic units of chromatin are nucleosomes, that are made up of DNA wrapped around histone cores. Histone lysine residue is a common location for posttranslational modifications, with acetylation being the second most prevalent. Histone acetyltransferases (HATs/KATs) and histone deacetylases (HDACs/KDACs) regulate histone acetylation, which is important in gene expression control. HDACs/KDACs regulate gene expressions through the repression of the transcription machinery. HDAC/KDAC isoforms play a major role during various stages of embryo development and neurogenesis. In specific, class I and II HDACs/KDACs are involved in cardiac muscle differentiation and development. An insight into different pathways and genes associated with embryonic development, the effect of HDAC/KDAC activity during the embryonic stem cell differentiation, preimplantation, embryo development, gastrulation, and the role of different HDAC/KDAC inhibitors during the process of embryogenesis is summarized in the present review article.
引用
收藏
页码:14 / 26
页数:13
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