Targeting Protein-Protein Interactions: A Promising Avenue of Anti-HIV Drug Discovery

被引：17

作者：

Zhan, Peng ^{[1
]}

Li, Wenjun ^{[1
]}

Chen, Hongfei ^{[1
]}

Liu, Xinyong ^{[1
]}

机构：

[1] Shandong Univ, Dept Med Chem, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2010年 / 17卷 / 29期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

HIV; AIDS; drug design; drug targets; protein-protein interactions; inhibitor; HUMAN-IMMUNODEFICIENCY-VIRUS; SMALL-MOLECULE INHIBITORS; REVERSE-TRANSCRIPTASE DIMERIZATION; CYCLOSPORINE-A ANALOG; TSAO DERIVATIVES; NUCLEAR IMPORT; CYCLOPHILIN-A; BINDING-SITE; CONFORMATIONAL-CHANGES; CELLULAR COFACTORS;

D O I：

10.2174/092986710793176357

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, the number of useful chemical biology information of protein-protein interactions in the HIV life cycle and related inhibitors, is growing rapidly, which makes protein-protein interactions a new investigative area for antiviral drug intervention. This review will summarize recent work in this field, mainly focusing on the utilization of small molecules targeted against a variety of protein-protein interactions that have great therapeutic feasibility for HIV infection, and lastly outline some other important protein-protein interactions with a potential to advance into novel anti-HIV drug targets in future.

引用

页码：3393 / 3409

页数：17

共 50 条

[31] Approaches to targeting protein-protein interactions
Arkin, Michelle
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 258
[32] Systematic Targeting of Protein-Protein Interactions
Modell, Ashley E.
Blosser, Sarah L.
Arora, Paramjit S.
TRENDS IN PHARMACOLOGICAL SCIENCES, 2016, 37 (08) : 702 - 713
[33] Targeting protein-protein interaction interfaces in COVID-19 drug discovery
Chang, Chung-ke
Lin, Shan-Meng
Satange, Roshan
Lin, Shih-Chao
Sun, Sin-Cih
Wu, Hung-Yi
Kehn-Hall, Kylene
Hou, Ming-Hon
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021, 19 : 2246 - 2255
[34] Editorial: Computational drug discovery for targeting of protein-protein interfaces -Volume II
Morra, Giulia
Meli, Massimiliano
Moroni, Elisabetta
Pandini, Alessandro
FRONTIERS IN CHEMISTRY, 2023, 11
[35] Discovery of another anti-HIV protein in the search for the CD8+cell anti-HIV Factor
Levy, Jay A.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (26) : 7888 - 7889
[36] Protein-protein interactions as drug targets
Skwarczynska, Malgorzata
Ottmann, Christian
FUTURE MEDICINAL CHEMISTRY, 2015, 7 (16) : 2195 - 2219
[37] Network analysis and in silico prediction of protein-protein interactions with applications in drug discovery
Murakami, Yoichi
Tripathi, Lokesh P.
Prathipati, Philip
Mizuguchi, Kenji
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2017, 44 : 134 - 142
[38] Drug interactions and anti-HIV therapy
Katende-Kyenda, N. L.
Lubbe, M. S.
Serfontein, J. H. P.
Truter, I.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2008, 33 (04) : 393 - 400
[39] Targeting Protein-Protein Interactions in Hematologic Malignancies
Cierpicki, Tomasz
Grembecka, Jolanta
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE, 2025, 20 : 275 - 301
[40] Targeting protein-protein interactions for cancer therapy
Fry, DC
Vassilev, LT
JOURNAL OF MOLECULAR MEDICINE-JMM, 2005, 83 (12): : 955 - 963

← 1 2 3 4 5 →