[Pd(IPr*(acac)Cl]: An Easily Synthesized, Bulky Precatalyst for C-N Bond Formation

被引：77
|
作者：
Meiries, Sebastien [1 ]
Chartoire, Anthony [1 ]
Slawin, Alexandra M. Z. [1 ]
Nolan, Steven P. [1 ]
机构：
[1] Univ St Andrews, EaStCHEM Sch Chem, St Andrews KY16 9ST, Fife, Scotland
来源：
ORGANOMETALLICS | 2012年 / 31卷 / 08期
关键词：
PALLADIUM-CATALYZED AMINATION; HETEROCYCLIC CARBENE LIGANDS; CROSS-COUPLING REACTIONS; TEMPERATURE SUZUKI-MIYAURA; ARYL CHLORIDES; BUCHWALD-HARTWIG; RESTRICTED FLEXIBILITY; (NHC)PD(ALLYL)CL NHC; COMPLEXES; EFFICIENT;
D O I：
10.1021/om300205c
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A very straightforward synthesis of [Pd(IPr*)(acac)Cl] has been developed from commercially available Pd(acac)(2) and the easily prepared IPr*center dot HCl (acac = acetylacetonate; IPr* = N,N'-bis(2,6-bis(diphenylmethyl)-4-methylphenyl)imidazol-2-ylidene). The reactivity of the resulting complex [Pd(IPr*)(acac)Cl] (1) as a highly active Pd-II precatalyst for the Buchwald-Hartwig arylamination coupling has been explored. A wide range of substrates with varying electronic and steric demands of both coupling partners has been screened successfully. The chemoselectivity of the reaction was also explored by using aryl heterodihalides.
引用
收藏
页码：3402 / 3409
页数：8
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