Label-free colorimetric detection of lead ions with a nanomolar detection limit and tunable dynamic range by using gold nanoparticles and DNAzyme

被引：388

作者：

Wang, Zidong ^{[1
]}

Lee, Jung Heon ^{[1
]}

Lu, Yi ^{[1
,2
]}

机构：

[1] Univ Illinois, Dept Mat Sci & Engn, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 17期

关键词：

D O I：

10.1002/adma.200703181

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the presence of Pb2+, a cleaved enzyme-substrate complex releases ssDNA that adsorbs onto and stabilizes gold nanoparticles (AuNPs) against salt-induced aggregation. In the absence of Pb2+, the uncleaved complex can not stabilize the AuNPs, resulting in purple-blue AuNP aggregates (see figure). The sensor has a low detection limit of 3 nM, a high selectivity, and a tunable dynamic range.

引用

页码：3263 / +

页数：6

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