Pregabalin or morphine and gabapentin for neuropathic pain

被引:8
|
作者
Doggrell, SA [1 ]
机构
[1] Univ Auckland, Div Hlth Practice, Auckland 1, New Zealand
关键词
gabapentin; morphine; neuropathic pain; pregabalin;
D O I
10.1517/14656566.6.14.2535
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Common causes of neuropathic pain are diabetes and herpes zoster, with 15% of patients with long-standing diabetes and 11% of herpes patients suffering from this pain. Gabapentin and pregabalin modulate the alpha(2)delta calcium-channel subunits, possibly decreasing the neurotransmitter release associated with the central sensitisation that occurs in neuropathic pain. Gabapentin has been shown to be effective in neuropathic pain and, recently, so has pregabalin. These agents seem to have similar efficacy when used alone, but this needs to be tested in a head-to-head trial. A clinical trial comparing morphine, gabapentin or their combination at lower doses showed that the combination of morphine and gabapentin reduced the pain score to a greater extent than either agent alone. This combination treatment represents a novel approach to neuropathic pain.
引用
收藏
页码:2535 / 2539
页数:5
相关论文
共 50 条
  • [21] Gabapentin and pregabalin for chronic neuropathic and early postsurgical pain: current evidence and future directions
    Gilron, Ian
    CURRENT OPINION IN ANESTHESIOLOGY, 2007, 20 (05) : 456 - 472
  • [22] Pregabalin vs gabapentin in the treatment of neuropathic pain in Italy: A cost-effectiveness analysis
    Pradelli, L.
    Marchettini, P.
    Iannazzo, S.
    VALUE IN HEALTH, 2006, 9 (06) : A375 - A375
  • [23] Efficacy and safety of pregabalin in patients with neuropathic cancer pain undergoing morphine therapy
    Dou, Zhi
    Jiang, Zongbin
    Zhong, Jincai
    ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 2017, 13 (02) : E57 - E64
  • [24] Pregabalin versus Gabapentin Efficacy in the Management of Neuropathic Pain Associated with Failed Back Surgery Syndrome
    Al-Ameri, Laith Thamer
    Shukri, Mohammed Emad
    Hameed, Ekhlas Khalid
    Marzook, Ahmed Abed
    JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, 2024, 67 (02) : 202 - 208
  • [25] Comparing Effectiveness of Gabapentin and Pregabalin in Treatment of Neuropathic Pain: A Retrospective Cohort of Palliative Care Outpatients
    Dragic, Lisa
    Webb, Thomas
    Chandler, Michael
    Harrington, Sarah Beth
    McDade, Elizabeth
    Dayer, Lindsey
    Painter, Jacob T.
    JOURNAL OF PAIN & PALLIATIVE CARE PHARMACOTHERAPY, 2020, 34 (04) : 192 - 196
  • [26] Pregabalin for neuropathic pain in adults
    Derry, Sheena
    Bell, Rae Frances
    Straube, Sebastian
    Wiffen, Philip J.
    Aldington, Dominic
    Moore, R. Andrew
    COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2019, (01):
  • [27] Design, synthesis, and preliminary evaluation of gabapentin-pregabalin mutual prodrugs in relieving neuropathic pain
    Shi, WG
    Liu, H
    Zhang, YP
    Zhong, BH
    Yang, HJ
    ARCHIV DER PHARMAZIE, 2005, 338 (08) : 358 - 364
  • [28] COMPARISON OF THE EFFICACY OF GABAPENTIN AND PREGABALIN FOR NEUROPATHIC PAIN IN PATIENTS WITH SPINAL CORD INJURY: A CROSSOVER STUDY
    Kaydok, Ercan
    Levendoglu, Funda
    Ozerbil, Murat Onder
    Karahan, Ali Yavuz
    ACTA MEDICA MEDITERRANEA, 2014, 30 (06): : 1343 - 1348
  • [29] Gabapentin in the treatment of neuropathic pain
    Johnson, FN
    Johnson, RD
    Armer, ML
    REVIEWS IN CONTEMPORARY PHARMACOTHERAPY, 2001, 12 (3-4): : 125 - 211
  • [30] Gabapentin for Chronic Neuropathic Pain
    Moore, Andrew
    Derry, Sheena
    Wiffen, Philip
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2018, 319 (08): : 818 - 819