Pharmacokinetics (PK) of lonafarnib (L), a farnesyl protein transferase inhibitor.

被引：0
|
作者：
Zhu, Y [1 ]
Statkevich, P [1 ]
Cutler, DL [1 ]
Calzetta, A [1 ]
Curtis, D [1 ]
Batra, VK [1 ]
机构：
[1] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2004年 / 75卷 / 02期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：P59 / P59
页数：1
相关论文
共 50 条
  • [41] R115777 as farnesyl protein transferase inhibitor: Synthesis and SAR.
    Venet, M
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 222 : U639 - U640
  • [42] XR 3054, structurally related to limonene, is a novel inhibitor of farnesyl protein transferase
    Donaldson, MJ
    Skoumas, V
    Watson, M
    Ashworth, PA
    Ryder, H
    Moore, M
    Coombes, RC
    EUROPEAN JOURNAL OF CANCER, 1999, 35 (06) : 1014 - 1019
  • [43] Sch 207278: A novel farnesyl protein transferase inhibitor from an unidentified fungus
    Chu, M
    Mierzwa, R
    Barrabee, E
    King, A
    Hallade, M
    Terracciano, J
    Patel, MG
    Patton, R
    Bishop, WR
    Puar, MS
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (19) : 2547 - 2550
  • [44] Orally active, trihalobenzocycloheptapyridine farnesyl protein transferase inhibitor antitumor agents.
    Njoroge, FG
    Taveras, A
    Kelly, J
    Remiszewski, S
    Mallams, AK
    Doll, RJ
    Girijavallabhan, V
    Afonso, A
    Wolin, R
    Alvarez, C
    Cesarz, D
    Connolly, M
    Cooper, AB
    delRosario, J
    Desai, JA
    Deskus, J
    Dritz, J
    Holinger, FP
    Kaminski, JJ
    Liu, YT
    Pinto, P
    Rane, D
    Rossman, RR
    Saksena, AK
    Snow, ME
    Vibulbhan, B
    Wang, J
    Ganguly, AK
    Bishop, WR
    Kirschmeier, P
    Carr, D
    James, L
    Patton, R
    Bryant, MS
    Nomeir, AA
    Liu, M
    Wang, S
    Nardo, C
    Kumari, P
    Chen, KJ
    Watkins, R
    Korfmacher, WA
    Lin, CC
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 215 : U890 - U890
  • [45] A facile synthesis of ras farnesyl-protein transferase inhibitor chaetomellic acid A
    Desai, SB
    Argade, NP
    JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (14): : 4862 - 4863
  • [46] Farnesyl protein transferase inhibitor ZARNESTRA™ R115777 -: History of a discovery
    Venet, M
    End, D
    Angibaud, P
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2003, 3 (10) : 1095 - 1102
  • [47] L-778123 is an inhibitor of both farnesyl protein transferase and geranylgeranyl protein transferase type I that inhibits tumor growth in Ras transgenic mice.
    Kohl, NE
    Buser, C
    Desolms, SJ
    Dinsmore, CJ
    Gibbs, JB
    Graham, SL
    Hartman, GD
    Heimbrook, D
    Koblan, KS
    Lobell, RB
    Omer, CA
    Stirdivant, SM
    Williams, TM
    CLINICAL CANCER RESEARCH, 2001, 7 (11) : 3829S - 3829S
  • [48] Stereospecific synthesis of a novel farnesyl protein transferase inhibitor, valinoctin A and its analogues
    Tsuda, M
    Muraoka, Y
    Takeuchi, T
    Sekizawa, R
    Umezawa, K
    JOURNAL OF ANTIBIOTICS, 1996, 49 (10): : 1031 - 1035
  • [49] Pilot study of lonafarnib, a farnesyl transferase inhibitor, in patients with chronic myeloid leukemia in the chronic or accelerated phase that is resistant or refractory to imatinib therapy
    Borthakur, G
    Kantarjian, H
    Daley, G
    Talpaz, M
    O'Brien, S
    Garcia-Manero, G
    Giles, F
    Faderl, S
    Sugrue, M
    Cortes, J
    CANCER, 2006, 106 (02) : 346 - 352
  • [50] INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
    GRAHAM, SL
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 210 : 4 - ORGN
12345