Synthesis and Immunosuppressive Activity of New Amino Alcohols Derivatives(II)

被引：0

作者：

Cu Lin-lin ^{[1
]}

Mi Hao-yu ^{[1
]}

Zhang Qun-li ^{[1
]}

Wang Wei-wei ^{[2
]}

Yang Li-juan ^{[2
]}

Liang Yong-tao ^{[1
]}

Wang En-si ^{[1
,2
]}

机构：

[1] Jilin Univ, Coll Life Sci, Changchun 130012, Peoples R China

[2] Jilin Univ, Coll Pharm, Changchun 130012, Peoples R China

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2011年 / 27卷 / 05期

关键词：

Immunosuppressant; Amino alcohol derivative; Bioactivity; Buchere-Bergs reaction; RENAL-TRANSPLANTATION; CYCLOSPORINE; THERAPY; FK506;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of new amino alcohols derivatives was synthesized with 6-bromo-2-tetralone as starting material, 6-substituted-2-tetralone as intermediate and Ullmann reaction, Suzuki reaction and spiro-hydantoin hydrolysis as key steps. The structures of key intermediate and target compounds were confirmed by (1)H NMR, (13)C NMR, IR and MS. Bioactivity researches show that the target compounds have certain inhibition effects on mice peripheral blood lymphocytes.

引用

页码：808 / 812

页数：5

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