Genetic variants on 17q21 are associated with asthma in a Han Chinese population

被引：14
|
作者：
Li, F. -X. [1 ]
Tan, J. -Y. [2 ]
Yang, X. -X. [1 ]
Wu, Y. -S. [1 ]
Wu, D. [3 ]
Li, M. [1 ]
机构：
[1] So Med Univ, Sch Biotechnol, Guangzhou, Guangdong, Peoples R China
[2] So Med Univ, Zhongshan City Affiliated Hosp, Cent ICU Boai Hosp, Zhongshan, Peoples R China
[3] Guangdong Med Coll, Affiliated Hosp, Inst Resp Dis, Zhanjiang, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2012年 / 11卷 / 01期
关键词：
Asthma; 17q21; Genetic variants; Susceptibility; ORMDL3; EXPRESSION; ONSET;
D O I：
10.4238/2012.February.10.5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A genome-wide study has shown an association between SNPs located on 17q21 and asthma. Such associations have been identified in several populations, but little is known about the Han Chinese population. We conducted a case-control study in a Han Chinese population to investigate the relationship between SNPs located on 17q21 and asthma; 241 asthmatic patients and 212 healthy controls were recruited from the outpatient clinics of the Nanfang Hospital, Guangdong Province, southern China. We genotyped six SNPs (rs8067378, rs8069176, rs2305480, rs4795400, rs12603332, and rs11650680) located on 17q21 with the Sequenom MassARRAY iPLEX platform. For two of these six loci (rs2305480 and rs8067378), there was evidence of association with asthma, and there was a weak association of asthma with rs8069176. We confirm that genetic variants on 17q21 are associated with asthma in the Han Chinese population.
引用
收藏
页码：340 / 347
页数：8
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