Genetic variants on 17q21 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han population

被引：17
|
作者：
Qiu, R. [1 ,2 ]
Zhang, H. [3 ]
Zhao, H. [1 ,2 ]
Li, J. [1 ,2 ]
Guo, C. [1 ,2 ]
Gong, Y. [1 ,2 ]
Liu, Q. [1 ,2 ]
机构：
[1] Shandong Univ, Key Lab Expt Teratol, Minist Educ, Sch Med, Jinan 250012, Shandong, Peoples R China
[2] Shandong Univ, Dept Med Genet, Sch Med, Jinan 250012, Shandong, Peoples R China
[3] Shandong Acad Med Sci, Inst Basic Med, Jinan, Shandong, Peoples R China
来源：
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | 2013年 / 42卷 / 06期
基金：
中国国家自然科学基金;
关键词：
ASTHMA; LOCI; DISEASE;
D O I：
10.3109/03009742.2013.786755
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objectives: The aim of this study was to test whether orosomucoid like 3 (ORMDL3) and 17q21 variants are associated with susceptibility to ankylosing spondylitis (AS) in a Chinese population. Method: A total of 753 unrelated AS patients and 1120 ethnically matched healthy controls were recruited. Seven single nucleotide polymorphisms (SNPs: rs7216389, rs12603332, rs12936231, rs9303277, rs11557467, rs1007654, and rs17608925), which were selected from chromosome 17q21 containing the genes ORMDL3, GSDMB, ZPBP2, and IKZF3, were genotyped by the Taqman SNP genotyping assay. Results: Five of the SNPs (rs7216389, rs12603332, rs12936231, rs9303277, and rs11557467) were associated with AS (all p <= 0.01), especially in males (all p < 0.001). Of these, rs7216389, rs12603332, rs12936231, and rs11557467 were strongly associated with severity of the disease based on radiographic findings (p < 0.05). Conclusions: Our study confirmed that variants in chromosome 17q21 are significantly associated with AS in a Chinese Han population.
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收藏
页码：469 / 472
页数：4
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