One-pot synthesis of quinoline-fused [1,4]thiazepines via the tandem Ugi/post-Ugi reactions

被引：3

作者：

Ghandi, Mehdi ^{[1
]}

Efteghar, Irene ^{[1
]}

Abbasi, Alireza ^{[1
]}

机构：

[1] Univ Tehran, Sch Chem, Coll Sci, POB 14155 6455, Tehran, Iran

来源：

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2019年 / 16卷 / 02期

关键词：

Pyrrolidine-2-ones; Ugi reaction; Piperazines; DIVERSITY-ORIENTED SYNTHESIS; COMBINATORIAL SYNTHESIS; DISCOVERY; LEAKY;

D O I：

10.1007/s13738-018-1511-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A one-pot strategy has been developed for the synthesis of novel tetrahydro-[1,4]thiazepino[7,6-b]quinoline-5-carboxamide derivatives. These reactions presumably proceed by the combination of a Ugi 4CR and three intramolecular S(N)2 aliphatic, an alkaline hydrolysis and an intramolecular cyclization SNAr nucleophilic substitution processes in moderate to good yields. Unambiguous assignment of the molecular structures was carried out by single-crystal X-ray diffraction.

引用

页码：325 / 332

页数：8

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