Changes in inflammatory markers following treatment of acute exacerbations of obstructive pulmonary disease

The aim of the study was to investigate changes in inflammatory markers following emergency treatment of obstructive pulmonary disease. The study comprised 43 patients. After acute treatment, they were given either 30 mg of prednisolone p.o. or 1600 mug of inhaled budesonide daily for 1 week. Over the following 3 weeks, all the patients were given 1600 mug of inhaled budesonide daily. Blood samples for measurements of eosinophil cationic protein (S-ECP), eosinophil peroxidase (S-EPO), total eosinophil count (B-Eos), myeloperoxidase (S-MPO) and human neutrophil lipocaline (HNL) were taken and spirometry was performed before emergency treatment and after 1 and 4 weeks. There was no difference in the improvement in forced expiratory volume in 1 sec (FEV1) between patients given prednisolone or budesonide. Patients with an improvement in FEV1 of greater than or equal to 20% of baseline after 1 and 4 weeks displayed a larger decrease in eosinophil markers. The correlation between Delta FEV1 and DeltaS-ECP was r= -0.37, P<0.05, <Delta>S-EPO-0.40, P<0.01 and <Delta>B-Eos -0.44, P<0.01, after 4 weeks. This correlation was highly significant in patients who had smoked <less than or equal to>5 pack-years, while the correlation was not significant in patients with a longer smoking history and chronic airflow limitation (best FEV1 <80% of predicted). We conclude that the change in eosinophil markers is correlated to the improvement in lung function in non-smokers or short-term smokers following the emergency treatment of obstructive pulmonary disease. This study indicates that following eosinophil markers is more useful in patients with asthma than patients with COPD. (C) 2001 Harcourt Publishers Ltd.