Development of the semi-synthetic penicillins and cephalosporins

被引：23

作者：

Hamilton-Miller, JMT. ^{[1
]}

机构：

[1] UCL Royal Free & Univ Coll Med Sch, Dept Med Microbiol, London WC1E 6BT, England

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2008年 / 31卷 / 03期

关键词：

6-aminopenicillanic acid; 7-aminocephalosporanic acid; beta-lactam antibiotics; history of medicine;

D O I：

10.1016/j.ijantimicag.2007.11.010

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Semi-synthetic penicillins and cephalosporins both derive from their respective chemical nuclei, 6-aminopenicillanic acid (6-APA) and 7-aminocephalosporanic acid (7-ACA). Work leading to their isolation was being carried out in parallel, but following very different pathways, during the last half of the 1950s. The development of 6-APA was reviewed recently in this journal, and in the present article I take a closer look at early work on 'penicillin amidase' and revisit the steps that led to 7-ACA. (C) 2007 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：189 / 192

页数：4

共 50 条

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