Development of the semi-synthetic penicillins and cephalosporins

被引：23
|
作者：
Hamilton-Miller, JMT. [1 ]
机构：
[1] UCL Royal Free & Univ Coll Med Sch, Dept Med Microbiol, London WC1E 6BT, England
来源：
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2008年 / 31卷 / 03期
关键词：
6-aminopenicillanic acid; 7-aminocephalosporanic acid; beta-lactam antibiotics; history of medicine;
D O I：
10.1016/j.ijantimicag.2007.11.010
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Semi-synthetic penicillins and cephalosporins both derive from their respective chemical nuclei, 6-aminopenicillanic acid (6-APA) and 7-aminocephalosporanic acid (7-ACA). Work leading to their isolation was being carried out in parallel, but following very different pathways, during the last half of the 1950s. The development of 6-APA was reviewed recently in this journal, and in the present article I take a closer look at early work on 'penicillin amidase' and revisit the steps that led to 7-ACA. (C) 2007 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
引用
收藏
页码：189 / 192
页数：4
相关论文
共 50 条
  • [1] SEMI-SYNTHETIC PENICILLINS
    ING, HR
    PROCEEDINGS OF THE CHEMICAL SOCIETY OF LONDON, 1961, (JAN): : 6 - &
  • [2] SEMI-SYNTHETIC PENICILLINS
    LYNN, B
    ANTIBIOTICA ET CHEMOTHERAPIA, 1965, 13 : 125 - &
  • [3] SEMI-SYNTHETIC PENICILLINS
    FEKETY, FR
    BULLETIN OF THE JOHNS HOPKINS HOSPITAL, 1965, 116 (01): : 69 - &
  • [4] Use of Enzymes in the Production of Semi-Synthetic Penicillins and Cephalosporins: Drawbacks and Perspectives
    Volpato, G.
    Rodrigues, R. C.
    Fernandez-Lafuente, R.
    CURRENT MEDICINAL CHEMISTRY, 2010, 17 (32) : 3855 - 3873
  • [5] OLIGOMERIC SEMI-SYNTHETIC PENICILLINS
    GRIGORAS, M
    COMANITA, E
    SIMIONESCU, C
    DOKLADI NA BOLGARSKATA AKADEMIYA NA NAUKITE, 1981, 34 (07): : 989 - 992
  • [6] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SEMI-SYNTHETIC SILICON-CONTAINING PENICILLINS AND CEPHALOSPORINS
    VEINBERG, GA
    KATS, AM
    POPOVA, EP
    LUKEVETS, EY
    RUDZIT, EA
    NESHCHADIM, GN
    RADKEVICH, TP
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1980, 14 (10): : 48 - 52
  • [7] TRANSMISSIBLE RESISTANCE TO SEMI-SYNTHETIC PENICILLINS
    DATTA, N
    ANTIBIOTIKI, 1971, 16 (06): : 523 - &
  • [8] ADVANCES IN PREPARATION OF SEMI-SYNTHETIC CEPHALOSPORINS
    POVAROV, LS
    ANTIBIOTIKI, 1979, 24 (05): : 376 - 393
  • [9] EFFECT OF SEMI-SYNTHETIC PENICILLINS ON PROSTAGLANDIN METABOLISM
    WEISSCHEDEL, E
    ANDRASSY, K
    KODERISCH, J
    RITZ, E
    BLUT, 1981, 42 (02): : 103 - 103
  • [10] SEMI-SYNTHETIC PENICILLINS .23. SULPHONYLOFORMAMIDINOPENICILLINS
    BUSKOOSZCZAPOWICZ, I
    CIESLAK, J
    ACTA POLONIAE PHARMACEUTICA, 1982, 39 (1-3): : 121 - 126
12345