A new route to 3,4-disubstituted piperidines: formal synthesis of (-)-paroxetine and (+)-femoxetine

被引：30
|
作者：
Yamada, S [1 ]
Jahan, I [1 ]
机构：
[1] Ochanomizu Univ, Dept Chem, Bunkyo Ku, Tokyo 1128610, Japan
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 50期
关键词：
(-)-paroxetine; (+)-femoxetine; face-selective addition; cation-pi interaction; 1,4-dihydropyridine;
D O I：
10.1016/j.tetlet.2005.10.049
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new route to 3,4-disubstituted piperidines was developed using chiral 1,4-dihydropyridines as key intermediates, the synthetic utility of which was demonstrated by formal synthesis of (-)-paroxetine and (+)-femoxetine. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8673 / 8676
页数：4
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