Klebsiella pneumoniae ST258 Producing KPC-3 Identified in Italy Carries Novel Plasmids and OmpK36/OmpK35 Porin Variants

被引：150
|
作者：
Garcia-Fernandez, Aurora [1 ]
Villa, Laura [1 ]
Carta, Claudio [2 ]
Venditti, Carolina [1 ]
Giordano, Alessandra [3 ]
Venditti, Mario [3 ]
Mancini, Carlo [3 ]
Carattoli, Alessandra [1 ]
机构：
[1] Ist Super Sanita, Dept Infect Parasit & Immune Mediated Dis, I-00161 Rome, Italy
[2] Ist Super Sanita, Dept Haematol Oncol & Mol Med, I-00161 Rome, Italy
[3] Univ Roma La Sapienza, Dept Publ Hlth & Infect Dis, Rome, Italy
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 04期
关键词：
SPECTRUM-BETA-LACTAMASE; SEQUENCE TYPE 258; CARBAPENEMASE; RESISTANCE; EMERGENCE; GENES;
D O I：
10.1128/AAC.05308-11
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A carbapenemase-resistant Klebsiella pneumoniae strain, clone ST258 producing KPC-3, was fully characterized. The entire plasmid content was investigated, thereby identifying plasmids of the IncFII(k) (two of them similar to pKPQIL and pKPN3, respectively), IncX, and COlE types, carrying a formidable set of resistance genes against toxic compounds, metals, and antimicrobial drugs and a novel iron(III) uptake system.
引用
收藏
页码：2143 / 2145
页数：3
相关论文
共 46 条
  • [1] OmpK35 and OmpK36 porin variants associated with specific sequence types of Klebsiella pneumoniae
    Papagiannitsis, Constantinos C.
    Giakkoupi, Panagiota
    Kotsakis, Stathis D.
    Tzelepi, Eva
    Tzouvelekis, Leonidas S.
    Vatopoulos, Alkiviadis C.
    Miriagou, Vivi
    JOURNAL OF CHEMOTHERAPY, 2013, 25 (04) : 250 - 254
  • [2] An Outbreak of NDM-1-Producing Klebsiella pneumoniae, Associated with OmpK35 and OmpK36 Porin Loss in Tunisia
    Hamzaoui, Zaineb
    Ocampo-Sosa, Alain
    Maamar, Elaa
    Fernandez Martinez, Marta
    Ferjani, Sana
    Hammami, Samia
    Harbaoui, Sarra
    Genel, Nathalie
    Arlet, Guillaume
    Saidani, Mabrouka
    Slim, Amine
    Boutiba-Ben Boubaker, Ilhem
    Martinez-Martinez, Luis
    MICROBIAL DRUG RESISTANCE, 2018, 24 (08) : 1137 - 1147
  • [3] Contribution of β-Lactamases and Porin Proteins OmpK35 and OmpK36 to Carbapenem Resistance in Clinical Isolates of KPC-2-Producing Klebsiella pneumoniae
    Zhang, Ying
    Jiang, Xiaofei
    Wang, Yanyan
    Li, Gang
    Tian, Yueru
    Liu, Hong
    Ai, Fuqi
    Ma, Yiming
    Wang, Bei
    Ruan, Feiyi
    Rajakumar, Kumar
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (02) : 1214 - 1217
  • [4] Mutation of kvrA Causes OmpK35 and OmpK36 Porin Downregulation and Reduced Meropenem-Vaborbactam Susceptibility in KPC-Producing Klebsiella pneumoniae
    Dulyayangkul, Punyawee
    Ismah, Wan Ahmad Kamil Wan Nur
    Douglas, Edward J. A.
    Avison, Matthew B.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2020, 64 (07)
  • [5] Prevalence of OmpK35 and OmpK36 porin expression in beta-lactamase and non-beta-lactamase-producing Klebsiella pneumoniae
    Shakib, Pegah
    Ghafourian, Sobhan
    Zolfaghary, Mohammad Reza
    Hushmandfar, Reza
    Ranjbar, Reza
    Sadeghifard, Nourkhoda
    BIOLOGICS-TARGETS & THERAPY, 2012, 6 : 1 - 4
  • [6] Carbapenems induce different ompK35 and ompK36 mutations in ESBL and non-ESBL producing Klebsiella pneumoniae
    Chen, Chia-Hua
    Chao, Chih-Wei
    Lee, Jen-Jain
    Liu, Chuan-Shee
    Chu, Chishih
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2017, 50 : S80 - S81
  • [7] Carbapenems induce different ompK35 and ompK36 mutations in ESBL and non-ESBL producing Klebsiella pneumoniae
    Chen, Chia-Hua
    Chao, Chih-Wei
    Lee, Jen-Jain
    Liu, Chuan-Shee
    Chu, Chishih
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2017, 50 : S177 - S177
  • [8] Contribution of OmpK36 to carbapenem susceptibility in KPC-producing Klebsiella pneumoniae
    Landman, David
    Bratu, Simona
    Quale, John
    JOURNAL OF MEDICAL MICROBIOLOGY, 2009, 58 (10) : 1303 - 1308
  • [9] Klebsiella pneumoniae Outer Membrane Porins OmpK35 and OmpK36 Play Roles in both Antimicrobial Resistance and Virulence
    Tsai, Yu-Kuo
    Fung, Chang-Phone
    Lin, Jung-Chung
    Chen, Jiun-Han
    Chang, Feng-Yee
    Chen, Te-Li
    Siu, L. Kristopher
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (04) : 1485 - 1493
  • [10] Reduced Susceptibility to Carbapenems in a Klebsiella pneumoniae Clinical Isolate Producing SCO-1 and CTX-M-15 β-Lactamases Together with OmpK35 and OmpK36 Porin Deficiency
    Venditti, Carolina
    Butera, Ornella
    Proia, Anna
    Rigacci, Luigi
    Mariani, Bruno
    Parisi, Gabriella
    Messina, Francesco
    Capone, Alessandro
    Nisii, Carla
    Caro, Antonino Di
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2020, 64 (08)
12345