Steric effects of the ligand in the enantioselective palladium-catalyzed allylic alkylation using chiral oxazolinylpyridines

被引：46
|
作者：
Chelucci, G [1 ]
Medici, S [1 ]
Saba, A [1 ]
机构：
[1] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy
来源：
TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 03期
关键词：
D O I：
10.1016/S0957-4166(99)00023-3
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Eight new chiral oxazolinylpyridines were prepared and assessed in the enantioselective palladium-catalyzed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethyl malonate. Catalytic activity and enantioselectivity were found to be highly dependent upon the steric requirement of the substituent on the pyridine ring: enantioselectivity up to 92% has been obtained. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：543 / 550
页数：8
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