Total synthesis and stereochemical assignment of cryptolatifolione

被引：7
|
作者：
Novaes, Luiz F. T. [1 ]
Sarotti, Ariel M. [2 ]
Pilli, Ronaldo A. [1 ]
机构：
[1] Univ Estadual Campinas, UNICAMP, Inst Quim, Dept Quim Organ, BR-13084971 Campinas, SP, Brazil
[2] Univ Nacl Rosario, CONICET, Fac Ciencias Bioquim & Farmaceut, Inst Quim Rosario, RA-2000 Rosario, Santa Fe, Argentina
来源：
RSC ADVANCES | 2015年 / 5卷 / 66期
基金：
巴西圣保罗研究基金会;
关键词：
ANALOGS;
D O I：
10.1039/c5ra09186a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An enantioselective total synthesis of cryptolatifolione and its C-8 epimer is presented in a protecting-group-free fashion. The synthesis relied on the use of a catalytic double Krische allylation, catalytic olefin metathesis and a C-H oxidation. Comparison of spectroscopic data of the synthetic isomers and natural product made possible the unambiguous elucidation of the absolute configuration of cryptolatifolione.
引用
收藏
页码：53471 / 53476
页数：6
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