Adjuvant treatment of early breast cancer: do the St Gallen recommendations influence clinical practice? Results from the NORA study

被引：7
|
作者：
Cazzaniga, M. E. [1 ]
Mustacchi, G. [2 ]
Pronzato, P. [3 ]
De Matteis, A. [4 ]
Di Costanzo, F. [5 ]
Floriani, I. [6 ]
机构：
[1] Treviglio Hosp, I-24047 Treviglio, BG, Italy
[2] Univ Trieste, Dept Med Oncol, Trieste, Italy
[3] IST, Genoa, Italy
[4] Ist Pascale, Naples, Italy
[5] Osped Careggi, Florence, Italy
[6] Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, Italy
来源：
ANNALS OF ONCOLOGY | 2007年 / 18卷 / 12期
关键词：
adjuvant therapy; breast cancer; St Gallen recommendations;
D O I：
10.1093/annonc/mdm365
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: The NORA study is a prospective longitudinal cohort study aiming at investigating treatment in patients with early breast cancer. Here, we present the impact of the St Gallen recommendations on clinical practice. Patients and methods: We compared adjuvant strategies in patients enrolled in 2000-2002 to those in 2003-2004 to verify the impact of the 2003 St Gallen recommendations. Results: The use of aromatase inhibitors (Als) doubled: 65/629 patients (10.3%) vs 100/458 patients (21.8) (P < 0.0001). Following chemotherapy, Als were administered in 8.5% of the retrospective cohort and in 15.1 % of the prospective one (P < 0.0001). The use of taxanes plus hormones dropped (P = 0.0026), but not when used as single agents. A marked increase was observed in the use of anthracycline-based chemotherapy (46.3% vs 65.2%), mainly three-drug regimens (33.3% vs 46.6%). Conclusion: Our results suggest that the St Gallen recommendations have had a major impact on clinical practice.
引用
收藏
页码：1976 / 1980
页数：5
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