Adjuvant treatment of early breast cancer: do the St Gallen recommendations influence clinical practice? Results from the NORA study

被引：7

作者：

Cazzaniga, M. E. ^{[1
]}

Mustacchi, G. ^{[2
]}

Pronzato, P. ^{[3
]}

De Matteis, A. ^{[4
]}

Di Costanzo, F. ^{[5
]}

Floriani, I. ^{[6
]}

机构：

[1] Treviglio Hosp, I-24047 Treviglio, BG, Italy

[2] Univ Trieste, Dept Med Oncol, Trieste, Italy

[3] IST, Genoa, Italy

[4] Ist Pascale, Naples, Italy

[5] Osped Careggi, Florence, Italy

[6] Ist Ric Farmacol Mario Negri, Dept Oncol, Milan, Italy

来源：

ANNALS OF ONCOLOGY | 2007年 / 18卷 / 12期

关键词：

adjuvant therapy; breast cancer; St Gallen recommendations;

D O I：

10.1093/annonc/mdm365

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The NORA study is a prospective longitudinal cohort study aiming at investigating treatment in patients with early breast cancer. Here, we present the impact of the St Gallen recommendations on clinical practice. Patients and methods: We compared adjuvant strategies in patients enrolled in 2000-2002 to those in 2003-2004 to verify the impact of the 2003 St Gallen recommendations. Results: The use of aromatase inhibitors (Als) doubled: 65/629 patients (10.3%) vs 100/458 patients (21.8) (P < 0.0001). Following chemotherapy, Als were administered in 8.5% of the retrospective cohort and in 15.1 % of the prospective one (P < 0.0001). The use of taxanes plus hormones dropped (P = 0.0026), but not when used as single agents. A marked increase was observed in the use of anthracycline-based chemotherapy (46.3% vs 65.2%), mainly three-drug regimens (33.3% vs 46.6%). Conclusion: Our results suggest that the St Gallen recommendations have had a major impact on clinical practice.

引用

页码：1976 / 1980

页数：5

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