Antivirals for COVID-19 in Solid Organ Transplant Recipients

被引:9
|
作者
Laracy, Justin C. [1 ]
Verna, Elizabeth C. [2 ]
Pereira, Marcus R. [1 ]
机构
[1] Columbia Univ Coll Phys & Surg, Dept Med, Div Infect Dis, 622 W 168th St PH 876, New York, NY 10032 USA
[2] Columbia Univ Coll Phys & Surg, Dept Med, Div Digest & Liver Dis, New York, NY 10032 USA
关键词
Remdesivir; Convalescent plasma; COVID-19; Solid organ transplant; SARS-CoV-2; RESPIRATORY SYNDROME CORONAVIRUS; SARS; SARS-COV-2; LOPINAVIR/RITONAVIR; CHLOROQUINE; DRUGS;
D O I
10.1007/s40472-020-00304-z
中图分类号
R61 [外科手术学];
学科分类号
摘要
Purpose of Review To evaluate the critical studies published so far on the most promising antiviral therapies for COVID-19, with particular emphasis on any solid organ transplant-specific information. Recent Findings Although the literature is increasing exponentially, most clinical trials have been preliminary, thus lacking robust evidence to support many of the drugs discussed here. The main exception is remdesivir, for which several trials have been published supporting its use for patients with severe COVID-19. No solid organ transplant-specific data on remdesivir or other antiviral therapies have been published so far. While further studies are urgently needed, in particular those specific to solid organ transplant recipients, the evidence so far only supports the use of remdesivir for patients with severe COVID-19.
引用
收藏
页码:355 / 365
页数:11
相关论文
共 50 条
  • [41] COVID-19 in Solid Organ Transplant Recipients in Spain Throughout 2020: Catching the Wave?
    Coll, Elisabeth
    Fernandez-Ruiz, Mario
    Padilla, Maria
    Moreso, Francesc
    Hernandez-Vicente, Ana
    Yanez, Inigo
    Molina, Maria
    Vazquez-Sanchez, Teresa
    Crespo, Marta
    Facundo, Carme
    Rodriguez-Ferrero, Maria Luisa
    Ruiz Fuentes, Maria Carmen
    Loinaz, Carmelo
    Bernal, Gabriel
    Melilli, Edoardo
    Bravo, Carlos
    Diekmann, Fritz
    Llado, Laura
    Garcia-Alvarez, Teresa M.
    Salcedo, Magdalena
    Beneyto, Isabel
    Castells, Lluis
    Alonso, Rodrigo
    Rodriguez-Benot, Alberto
    Diaz-Corte, Carmen
    Graus, Javier
    Ortiz-Bautista, Carlos
    Garcia-Cosio, Maria Dolores
    Hinojal, Rosa
    Pena, Lucia
    Dominguez-Gil, Beatriz
    TRANSPLANTATION, 2021, 105 (10) : 2146 - 2155
  • [42] Mortality in solid organ transplant recipients with COVID-19: More than meets the eye
    Maggiore, Umberto
    Riella, Leonardo V.
    Azzi, Jamil
    Cravedi, Paolo
    AMERICAN JOURNAL OF TRANSPLANTATION, 2022, 22 (05) : 1496 - 1497
  • [43] Immunosuppression in solid organ transplant recipients with Covid-19: More data, but still complicated
    Heldman, Madeleine R.
    Kates, Olivia S.
    Fisher, Cynthia E.
    Limaye, Ajit P.
    TRANSPLANT INFECTIOUS DISEASE, 2021, 23 (04)
  • [44] Apples to apples: The challenges of studying COVID-19 mortality in solid organ transplant recipients
    Heldman, Madeleine R.
    Rakita, Robert M.
    Lease, Erika D.
    Fisher, Cynthia E.
    Limaye, Ajit P.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2022, 22 (07) : 1929 - 1930
  • [45] Correspondence on Outcomes of COVID-19 in Unvaccinated Compared With Vaccinated Solid Organ Transplant Recipients
    Mungmunpuntipantip, Rujittika
    Wiwanitkit, Viroj
    TRANSPLANTATION, 2022, 106 (10) : E461 - E461
  • [46] Coronavirus Disease 2019 (COVID-19) in Solid-organ Transplant Recipients Reply
    Kates, Olivia S.
    Rakita, Robert M.
    Lease, Erika D.
    Fisher, Cynthia E.
    Limaye, Ajit P.
    CLINICAL INFECTIOUS DISEASES, 2021, 73 (09) : E2833 - E2834
  • [47] Tocilizumab for severe COVID-19 in solid organ transplant recipients: a matched cohort study
    Pereira, Marcus R.
    Aversa, Meghan M.
    Farr, Maryjane A.
    Miko, Benjamin A.
    Aaron, Justin G.
    Mohan, Sumit
    Cohen, David J.
    Husain, Syed A.
    Ratner, Lloyd E.
    Arcasoy, Selim
    Uriel, Nir
    Zheng, Elizabeth X.
    Fox, Alyson N.
    Tsapepas, Demetra S.
    Emond, Jean C.
    Verna, Elizabeth C.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2020, 20 (11) : 3198 - 3205
  • [48] Prior Infection Reduces Omicron COVID-19 Severity in Solid Organ Transplant Recipients
    Boan, Peter
    TRANSPLANTATION, 2024, 108 (05) : 1070 - 1071
  • [49] Clinical experience in the treatment of COVID-19 with monoclonal antibodies in solid organ transplant recipients
    Munez-Rubio, Elena
    Calderon-Parra, Jorge
    Gutierrez-Villanueva, Andrea
    Fernandez-Cruz, Ana
    Ramos-Martinez, Antonio
    REVISTA ESPANOLA DE QUIMIOTERAPIA, 2023, 36 : 25 - 28
  • [50] COVID-19 Clinical Outcomes in Solid Organ Transplant Recipients During the Omicron Surge
    Cochran, Willa
    Shah, Pali
    Barker, Lindsay
    Langlee, Julie
    Freed, Kristin
    Boyer, Lauren
    Scott Anderson, R.
    Belden, Maura
    Bannon, Jaclyn
    Kates, Olivia S.
    Permpalung, Nitipong
    Mostafa, Heba
    Segev, Dorry L.
    Brennan, Daniel C.
    Avery, Robin K.
    TRANSPLANTATION, 2022, 106 (07) : E346 - E347