Aggressive Natural Killer Cell Leukemia in an Adolescent Patient: A Case Report and Literature Review

被引：2
|
作者：
Yang, Rong [1 ,2 ]
Ai, Yuan [1 ,2 ]
Liu, Chuan [1 ,3 ]
Lu, Xiaoxi [1 ,2 ]
机构：
[1] Sichuan Univ, West China Second Univ Hosp, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu, Peoples R China
[2] Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Chengdu, Peoples R China
[3] Sichuan Univ, West China Univ Hosp 2, Dept Radiol, Chengdu, Peoples R China
来源：
FRONTIERS IN PEDIATRICS | 2022年 / 10卷
关键词：
aggressive natural killer cell leukemia; children; Epstein-Barr virus; hemophagocytic lymphohistiocytosis; case report; T-CELLS; LYMPHOMA; TRANSPLANTATION; MUTATION; LEUKEMIA/LYMPHOMA; TRANSLATION; EXPRESSION; FREQUENT; MARROW; SERIES;
D O I：
10.3389/fped.2022.829927
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Aggressive natural killer cell leukemia (ANKL) is a rare malignant tumor, especially uncommon in children. ANKL has very aggressive clinical course and bad prognosis and is usually caused by Epstein-Barr virus infection. ANKL often has clinical manifestations of hemophagocytic lymphohistiocytosis (HLH) and can be easily treated as HLH, which might complicate this aggressive disease. Here we report an ANKL in adolescent whose clinical presentation was highly aggressive and response to L-asparaginase containing chemotherapy was very bad. Early-onset Flow cytometry of peripheral blood and bone marrow help make the diagnosis.
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页数：7
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