Clinical and spectroscopic improvement in HIV-associated cognitive impairment

被引：55
|
作者：
Stankoff, B
Tourbah, A
Suarez, S
Turell, E
Stievenart, JL
Payan, C
Coutellier, A
Herson, S
Baril, L
Bricaire, F
Calvez, V
Cabanis, EA
Lacomblez, L
Lubetzki, C
机构：
[1] Hop La Pitie Salpetriere, APHP, Federat Neurol 1, F-75651 Paris 13, France
[2] Hop La Pitie Salpetriere, APHP, Lab Neuropathol R Escourolle, F-75651 Paris 13, France
[3] Hop La Pitie Salpetriere, APHP, Federat Neurol 2, F-75651 Paris 13, France
[4] Hop La Pitie Salpetriere, APHP, Serv Pharmacol, F-75651 Paris 13, France
[5] Hop La Pitie Salpetriere, APHP, Serv Med Interne, F-75651 Paris 13, France
[6] Hop La Pitie Salpetriere, APHP, Serv Malad Infect, F-75651 Paris 13, France
[7] Hop La Pitie Salpetriere, APHP, Lab Virol CERVI, F-75651 Paris 13, France
[8] Univ Paris 06, Paris, France
[9] Ctr Hosp natl Quinze Vingts, Serv Neuroradiol, Paris, France
来源：
NEUROLOGY | 2001年 / 56卷 / 01期
关键词：
D O I：
10.1212/WNL.56.1.112
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
To assess the impact of highly active antiretroviral therapy (HAART) on AIDS-associated cognitive impairment, 22 patients with AIDS with (n = 11) and without (n = 11) cognitive deficit were evaluated clinically and by MRS every 3 months for 9 months. Nineteen patients were on HAART at study entry, 21 after 2 months. Cognitively impaired patients presented with a subcorticofrontal deficit and decreased N-acetyl-aspartate in frontal white matter. These clinical and metabolic abnormalities reversed partially on HAART, whereas they remained within normal limits in cognitively unimpaired patients.
引用
收藏
页码：112 / 115
页数：4
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