Targeting epidermal growth factor receptor signaling:: early results and future trends in oncology

被引:0
|
作者
Lage, A [1 ]
Crombet, T [1 ]
González, G [1 ]
机构
[1] Ctr Mol Immunol, Havana 11600, Cuba
关键词
cancer therapy; cancer vaccines; clinical trials; epidermal growth factor; epidermal growth factor receptor; monoclonal antibodies; tyrosine kinases;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Epidermal growth factor receptor (EGFR), a member of a family of membrane receptors with tyrosine kinase activity, is emerging as a target candidate for anti-cancer therapy, due to its overexpression in many carcinomas and its relationship with several hallmark properties of malignant behavior such as continuous cell proliferation, escape from apoptosis, cell migration and angiogenesis. Specially appealing is the overexpression of EGFR in tumors such as lung, colon, kidney and head and neck carcinomas which are mostly resistant to current chemotherapy. Several anti-EGFR agents are already in clinical testing: small molecule tyrosine kinases inhibitors, monoclonal antibodies and cancer vaccines. Early results provide evidence of antitumor activity in humans, to be confirmed in larger trials. Toxicity profiles do not overlap with chemotherapy or radiotherapy, but skin rash and diarrhea can be severe. Future investigations should clarify optimal schedules and explore combinations with standard onco-specific treatments. The ultimate challenge will be to combine diverse therapeutic interventions dealing with a regulatory system which is complex, highly redundant and robust. Combinations between vaccines and antibodies. or between vaccines to several molecular components of the system should be evaluated, as well as combinations between inhibitors of the EGFR signaling pathway and inhibitors of other regulatory pathways related to cell proliferation, apoptosis and angiogenesis.
引用
收藏
页码:327 / 336
页数:10
相关论文
共 50 条
  • [21] Targeting Epidermal Growth Factor Receptor-Related Signaling Pathways in Pancreatic Cancer
    Philip, Philip A.
    Lutz, Manfred P.
    PANCREAS, 2015, 44 (07) : 1046 - 1052
  • [22] Targeting epidermal growth factor receptor co-dependent signaling pathways in glioblastoma
    Liu, Feng
    Mischel, Paul S.
    WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 2018, 10 (01)
  • [23] Targeting the epidermal growth factor receptor in radiotherapy: radiobiological mechanisms, preclinical and clinical results
    Baumann, M
    Krause, M
    RADIOTHERAPY AND ONCOLOGY, 2004, 72 (03) : 257 - 266
  • [24] Targeting epidermal growth factor receptor in breast cancer
    Diéras, V
    Pierga, JY
    Vincent-Salomon, A
    Beuzeoc, P
    Pouillart, P
    De Cremoux, P
    BULLETIN DU CANCER, 2003, 90 : S257 - S262
  • [25] Targeting the epidermal growth factor receptor in colorectal carcinoma
    Kurtin, Sandra E.
    CANCER NURSING, 2007, 30 (04) : S1 - S9
  • [26] Molecular targeting in radiotherapy: Epidermal growth factor receptor
    Chung, TD
    Broaddus, WC
    MOLECULAR INTERVENTIONS, 2005, 5 (01) : 15 - +
  • [27] Targeting the epidermal growth factor receptor for cancer therapy
    Mendelsohn, J
    JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (18) : 1S - 13S
  • [28] Targeting the Epidermal Growth Factor Receptor in Glioblastoma Treatment
    Merkur, N.
    Westhoff, M. -A.
    Karpel-Massler, G.
    Halatsch, M. -E.
    CURRENT SIGNAL TRANSDUCTION THERAPY, 2012, 7 (01) : 3 - 13
  • [29] Monoclonal antibodies targeting the epidermal growth factor receptor
    Bianco, R
    Daniele, G
    Ciardiello, F
    Tortora, G
    CURRENT DRUG TARGETS, 2005, 6 (03) : 275 - 287
  • [30] Epidermal growth factor receptor targeting and challenges in glioblastoma
    Thorne, Amy Haseley
    Zanca, Ciro
    Furnari, Frank
    NEURO-ONCOLOGY, 2016, 18 (07) : 914 - 918