Silver-catalyzed decarboxylative C-H functionalization of cyclic aldimines with aliphatic carboxylic acids

被引：21

作者：

Wang, Jingjing ^{[1
]}

Liu, Xue ^{[3
]}

Wu, Ziyan ^{[1
]}

Li, Feng ^{[1
]}

Qin, Tingting ^{[1
]}

Zhang, Siyuan ^{[1
]}

Kong, Weiguang ^{[2
]}

Liu, Lantao ^{[1
,3
]}

机构：

[1] Shangqiu Normal Univ, Coll Chem & Chem Engn, Henan Key Lab Biomol Recognit & Sensing, Shangqiu 476000, Peoples R China

[2] Nanyang Normal Univ, Coll Chem & Pharmaceut Engn, Nanyang 473061, Peoples R China

[3] Zhengzhou Univ, Coll Chem, Zhengzhou 450052, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2021年 / 32卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Radical; Decarboxylation; C-H functionalization; Cyclic aldimines; Aliphatic carboxylic acids; MANNICH REACTION; STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC ARYLATION; N-SULFIMINES; IMINES; CYCLOADDITION; ALKYLATION; ACCESS; CARBON; TRIFLUOROMETHYLATION;

D O I：

10.1016/j.cclet.2021.03.011

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Silver-catalyzed decarboxylative C-H alkylation of cyclic aldimines with abundant aliphatic carboxylic acids has been realized under mild reaction conditions generating the corresponding products in moderate to good yields (32%-91%). In addition, a gram-scale reaction, late-stage modification of drug, synthetic transformation of the product, and further application of the catalytic strategy were also performed. Preliminary studies indicate that the reaction undergoes a radical process. (C) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：2777 / 2781

页数：5

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