ANTHELMINTIC DRUG DISCOVERY: INTO THE FUTURE

被引：81

作者：

Geary, Timothy G. ^{[1
]}

Sakanari, Judy A. ^{[1
]}

Caffrey, Conor R. ^{[1
]}

机构：

[1] McGill Univ, Inst Parasitol, Quebec City, PQ H9X 3V9, Canada

来源：

JOURNAL OF PARASITOLOGY | 2015年 / 101卷 / 02期

关键词：

SCHISTOSOMA-MANSONI INVITRO; ON-A-CHIP; HIGH-THROUGHPUT; ECHINOCOCCUS-MULTILOCULARIS; ANTIPARASITIC DRUGS; RESISTANCE; BRUGIA; CULTIVATION; WHOLE; 3RD-STAGE;

D O I：

10.1645/14-703.1

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The last half-century has provided all of the (few) drugs currently used to treat human helminthiases. Concern regarding the long-term utility of these drugs, given how readily resistance evolves in the veterinary-agricultural sector, spurs the discovery of new chemical entities. We review the approaches and technologies in use to identify anthelmintics and discuss a number of drug discovery paradigms that may prove pivotal to the next half-century of anthelmintic development.

引用

页码：125 / 133

页数：9

共 50 条

[41] The future of combinatorial chemistry as a drug discovery paradigm
Hall, SE
PHARMACEUTICAL RESEARCH, 1997, 14 (09) : 1104 - 1105
[42] Plant Metabolomics: The Future of Anticancer Drug Discovery
Dabbousy, Ranin
Rima, Mohamad
Roufayel, Rabih
Rahal, Mohamad
Legros, Christian
Sabatier, Jean-Marc
Fajloun, Ziad
PHARMACEUTICALS, 2024, 17 (10)
[43] The future of molecular dynamics simulations in drug discovery
Borhani, David W.
Shaw, David E.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2012, 26 (01) : 15 - 26
[44] Bromodomain Drug Discovery - the Past, the Present, and the Future
Pervaiz, Mehrosh
Mishra, Pankaj
Guenther, Stefan
CHEMICAL RECORD, 2018, 18 (12): : 1808 - 1817
[45] The future of molecular dynamics simulations in drug discovery
David W. Borhani
David E. Shaw
Journal of Computer-Aided Molecular Design, 2012, 26 : 15 - 26
[46] The Future Is Now: Artificial Intelligence in Drug Discovery
Bajorath, Juergen
Kearnes, Steven
Walters, W. Patrick
Georg, Gunda I.
Wang, Shaomeng
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (11) : 5249 - 5249
[47] The Present and Future of Drug Discovery for Chagas Disease
Campillo, Nuria E.
Gonzalez-Naranjo, Pedro
Antonio Paez, Juan
ANALES DE LA REAL ACADEMIA NACIONAL DE FARMACIA, 2012, 78 (01): : 34 - 61
[48] Drug Discovery for Kinetoplastid Diseases: Future Directions
Rao, Srinivasa P. S.
Barrett, Michael P.
Dranoff, Glenn
Faraday, Christopher J.
Gimpelewicz, Claudio R.
Hailu, Asrat
Jones, Catherine L.
Kelly, John M.
Lazdins-Helds, Jams K.
Maser, Pascal
Mengel, Jose
Mottram, Jeremy C.
Mowbray, Charles E.
Sacks, David L.
Scott, Phillip
Spath, Gerald F.
Tarleton, Rick L.
Spector, Jonathan M.
Diagana, Thierry T.
ACS INFECTIOUS DISEASES, 2019, 5 (02): : 152 - 157
[49] The future of molecular pharmacology and drug discovery in psychiatry
Caron, M.
Urs, N. M.
Peterson, S. M.
Snyder, J. C.
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2013, 23 : S108 - S109
[50] The impact of genetics on future drug discovery in schizophrenia
Matsumoto, Mitsuyuki
Walton, Noah M.
Yamada, Hiroshi
Kondo, Yuji
Marek, Gerard J.
Tajinda, Katsunori
EXPERT OPINION ON DRUG DISCOVERY, 2017, 12 (07) : 673 - 686

← 1 2 3 4 5 →