Influence of the hypermodified Y base on the A•U pairing in the codon-anticodon interaction

被引：7
|
作者：
Neto, MD
de Giambiagi, MS
Giambiagi, M
机构：
[1] Univ Brasilia, Dept Quim, BR-70910900 Brasilia, DF, Brazil
[2] Ctr Brasileiro Pesquisas Fis, CBPF, CNPq, BR-22290180 Rio De Janeiro, Brazil
来源：
CHEMICAL PHYSICS LETTERS | 1998年 / 290卷 / 1-3期
关键词：
D O I：
10.1016/S0009-2614(98)00509-0
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Through AM1 calculations we show that, when the first uracil of codon UUC binds to A36 of anticodon GAA of tRNA(Phe), dramatic conformational variations occur in the side chain of the hypermodified Y base in position 37, The H-bond found, involving one of the Y side-chain carboxylic oxygens and one of the A36 amino hydrogens, confers to A . U the stabilization energy of G . C. The calculated group-group indices and molecular valences agree with these features. We suggest that this stabilization of A . U, due to the presence of the Y base, may prevent misreading in the genetic code. (C) 1998 Elsevier Science B.V. All rights reserved.
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页码：205 / 210
页数：6
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