Revisiting the Concepts of Risk and Protective Factors for Understanding the Etiology and Development of Substance Use and Substance Use Disorders: Implications for Prevention

被引：50

作者：

Sloboda, Zili ^{[1
]}

Glantz, Meyer D. ^{[2
,4
,5
,6
]}

Tarter, Ralph E. ^{[3
]}

机构：

[1] JBS Int Inc, Res & Dev Grp, Res & Dev, Bethesda, MD 20852 USA

[2] NIDA, Div Epidemiol Serv & Prevent Res, NIH, Bethesda, MD 20892 USA

[3] Univ Pittsburgh, Ctr Educ & Drug Abuse Res, Pittsburgh, PA USA

[4] NIDA, Div Epidemiol & Prevent Res DESPR, NIH, Bethesda, MD 20892 USA

[5] NIDA, Epidemiol Res Branch, Bethesda, MD 20892 USA

[6] NIDA, Vulnerabil Res Program, Bethesda, MD 20892 USA

来源：

SUBSTANCE USE & MISUSE | 2012年 / 47卷 / 8-9期

关键词：

development; environment; genetics; neurobiology; protection; psychopathology; risk; vulnerability; ANTISOCIAL PERSONALITY-DISORDER; DEFICIT HYPERACTIVITY DISORDER; CANNABIS USE DISORDER; ALCOHOL-USE DISORDERS; ILLICIT DRUG-USE; ANXIETY DISORDERS; YOUNG ADULTHOOD; MAJOR DEPRESSION; MENTAL-DISORDERS; MARIJUANA USE;

D O I：

10.3109/10826084.2012.663280

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Over the past 20 years we have accumulated a greater knowledge and understanding of the genetic, neurobiological, and behavioral factors that may be associated with young people initiating the use of drugs and other substances and to progressing from use to abuse and dependence. This knowledge suggests that individuals may be "predisposed" to substance use disorders (SUD) and that the actual engagement in these behaviors depends on their environmental experiences from micro to macro levels. This paper summarizes this knowledge base and supports a developmental framework that examines the interaction of posited genetic, psychological, and neurobiological "predispositions" to SUD and those environmental influences that exacerbate this vulnerability.

引用

页码：944 / 962

页数：19

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