LENTIVIRAL 'GENE ONTOLOGY' (LEGO) VECTORS ENABLE HIGHLY EFFICIENT EX VIVO TRANSDUCTION OF HEPATOCYTES SUITABLE FOR CELL TRANSPLANTATION

被引:0
|
作者
Warlich, M. [1 ]
Weber, K. [2 ]
Thomaschewski, M. [2 ]
Luetgehetmann, M. [1 ]
Volz, T. [1 ]
Pollok, J. M. [3 ]
Gersting, S. [4 ]
Borsch, J. [4 ]
Santer, R. [5 ]
Ullrich, K. [5 ]
Lohse, A. W. [1 ]
Dandri, M. [1 ]
Fehse, B. [2 ]
Benten, D. [1 ]
机构
[1] Univ Med Ctr Hamburg Eppendorf, Dept Internal Med 1, Hamburg, Germany
[2] Univ Med Ctr Hamburg Eppendorf, Res Dept Cell & Gene Therapy, Hamburg, Germany
[3] Univ Med Ctr Hamburg Eppendorf, Dept Hepatobiliary & Transplant Surg, Hamburg, Germany
[4] Univ Munich, Dr von Hauner Childrens Hosp, Munich, Germany
[5] Univ Med Ctr Hamburg Eppendorf, Dept Paediat, Hamburg, Germany
关键词
D O I
10.1016/S0168-8278(11)60517-5
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
515
引用
收藏
页码:S211 / S212
页数:2
相关论文
共 28 条
  • [21] Efficient Ex Vivo Engineering and Expansion of Highly Purified Human Hematopoietic Stem and Progenitor Cell Populations for Gene Therapy
    Zonari, Erika
    Desantis, Giacomo
    Petrillo, Carolina
    Boccalatte, Francesco E.
    Lidonnici, Maria Rosa
    Kajaste-Rudnitski, Anna
    Aiuti, Alessandro
    Ferrari, Giuliana
    Naldini, Luigi
    Gentner, Bernhard
    STEM CELL REPORTS, 2017, 8 (04): : 977 - 990
  • [22] Ex Vivo Gene Therapy in a Pig Model of Metabolic Liver Disease: Intraportal Infusion of Spheroid Hepatocytes is a Viable Alternative to Single Cell Transplantation
    Nicolas, Clara T.
    Hickey, Raymond D.
    Allen, Kari L.
    Du, Zeji
    Guthman, Rebekah M.
    Amiot, Bruce
    Bansal, Aditya
    DeGrado, Timothy R.
    Nyberg, Scott L.
    Lillegard, Joseph B.
    JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2017, 225 (04) : E39 - E39
  • [23] Highly efficient ex vivo gene transfer into primary human tumor cells using improved recombinant adeno-associated virus (rAAV) vectors.
    Maass, G
    Bogedain, C
    Wendtner, CM
    Scheer, U
    Volkenandt, M
    Michl, D
    BarunFalco, M
    Emmerich, B
    Kotin, R
    Winnacker, EL
    Hallek, M
    BLOOD, 1996, 88 (10) : 526 - 526
  • [24] Highly efficient cell-mediated gene transfer using non-viral vectors and FuGene™6: in vitro and in vivo studies
    I. Hellgren*
    V. Drvota
    R. Pieper
    S. Enoksson
    P. Blomberg
    K. B. Islam
    C. Sylvén
    Cellular and Molecular Life Sciences CMLS, 2000, 57 : 1326 - 1333
  • [25] Highly efficient cell-mediated gene transfer using non-viral vectors and FuGene™6:: in vitro and in vivo studies
    Hellgren, I
    Drvota, V
    Pieper, R
    Enoksson, S
    Blomberg, P
    Islam, KB
    Sylvén, C
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2000, 57 (8-9) : 1326 - 1333
  • [26] Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells
    Kurita, Ryo
    Sasaki, Erika
    Yokoo, Tomoko
    Hiroyama, Takashi
    Takasugi, Kashiya
    Imoto, Hideyuki
    Izawa, Kiyoko
    Dong, Yan
    Hashiguchi, Takao
    Soda, Yasushi
    Maeda, Toyoki
    Suehiro, Youko
    Tanioka, Yoshikuni
    Nakazaki, Yukoh
    Tani, Kenzaburo
    STEM CELLS, 2006, 24 (09) : 2014 - 2022
  • [27] Outcomes of Gene Therapy for Severe Sickle Cell Disease (SCD) via Transplantation of Autologous Hematopoietic Stem Cells Transduced Ex Vivo with a Lentiviral βAT87Q_Globin Vector
    Soni, Sandeep
    Tisdale, John F.
    Hsieh, Matthew
    Kanter, Julie
    Leboulch, Philippe
    Cavazzana, Marina
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2016, 22 (03) : S63 - S63
  • [28] Initial Results from Study Hgb-206: A Phase 1 Study Evaluating Gene Therapy By Transplantation of Autologous CD34+Stem Cells Transduced Ex Vivo with the Lentiglobin BB305 Lentiviral Vector in Subjects with Severe Sickle Cell Disease
    Kanter, Julie
    Walters, Mark C.
    Hsieh, Matthew
    Thompson, Alexis A.
    Krishnamurti, Lakshmanan
    Kwiatkowski, Janet
    Kamble, Rammurti T.
    von Kalle, Christof
    Kuypers, Frans A.
    Cavazzana, Marina
    Leboulch, Philippe
    Sandler, Laura
    Soni, Sandeep
    Tisdale, John F.
    BLOOD, 2015, 126 (23)