Pomegranate (Punica granatum L.) Peel Extract: Potential Cytotoxic Agent against Different Cancer Cell Lines

被引：21
|
作者：
Keta, Otilija [1 ]
Deljanin, Milena [2 ]
Petkovic, Vladana [1 ]
Zdunic, Gordana [3 ]
Jankovic, Teodora [3 ]
Zivkovic, Jelena [3 ]
Ristic-Fira, Aleksandra [1 ]
Petrovic, Ivan [1 ]
Savikin, Katarina [3 ]
机构：
[1] Univ Belgrade, Vinca Inst Nucl Sci, Mike Petrovioa Alasa 12-14, Belgrade 11001, Serbia
[2] Coll Appl Sci Tech Studies & Technol, Kosanciceva 36, Krusevac 37000, Serbia
[3] Inst Med Plant Res Dr Josif Pancic, Tadeusa Koscuska 1, Belgrade 11000, Serbia
来源：
RECORDS OF NATURAL PRODUCTS | 2020年 / 14卷 / 05期
关键词：
Punica granatum L; peel extract; phenolic compounds; cytotoxicity; cancer cells; IN-VITRO; ANTIOXIDANT ACTIVITIES; ELLAGIC ACID; METASTASIS; APOPTOSIS; FRUIT; JUICE; PROLIFERATION; ELLAGITANNINS; PLANTS;
D O I：
10.25135/rnp.170.19.11.1477
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The aim of the present study was to investigate effects of pomegranate peel (PP) extract on different human cancer cell lines. MTT was performed to estimate cytotoxic effects of PP extract against HTB140, HTB177, MCF7, HCT116 human cancer cell lines and MRC-5 normal fibroblasts. Clonogenic assay was used to reveal cell survival after the treatment with PP extract. Cell cycle analysis was done using flow cytometry. Wound healing assay was applied to estimate inhibitory effects of PP extract on migration of cancer cells. The results showed that PP extract expressed selective cytotoxicity for cancer cells compared to normal cell line. Analyzed cancer cell lines displayed individual variations in sensitivity to PP extract reflected through changes in clonogenic survival, cell cycle distribution and migration, which may be due to the specific nature of each tested cell line. In conclusion, PP extract exhibits good inhibitory effects on tested cancer cell lines.
引用
收藏
页码：326 / 339
页数：14
相关论文
共 50 条
  • [41] Nutritional Values, Microbial Population and Bioactive Components of Pomegranate (Punica granatum L.) Peel Extracts
    Sami, Rokayya
    Khojah, Ebtihal
    Mansour, Ahmed M. A.
    Al-Mushhin, Amina A. M.
    Elhakem, Abeer
    El-Sherif, Dina M.
    Alkaltham, Mohammed Saeed
    Salamatullah, Ahmad Mohammad
    INTERNATIONAL JOURNAL OF PHARMACOLOGY, 2021, 17 (04) : 208 - 216
  • [42] Processing of Parboiled Wheat Noodles Fortified with Pulsed Ultrasound Pomegranate (Punica granatum L. var. Malas) Peel Extract
    Kazemi, Milad
    Karim, Roselina
    Mirhosseini, Hamed
    Hamid, Azizah Abdul
    Tamnak, Sahar
    FOOD AND BIOPROCESS TECHNOLOGY, 2017, 10 (02) : 379 - 393
  • [43] Flavonols and Flavones Changes in Pomegranate (Punica granatum L.) Fruit Peel during Fruit Development
    Zhao, X.
    Yuan, Z.
    Fang, Y.
    Yin, Y.
    Feng, L.
    JOURNAL OF AGRICULTURAL SCIENCE AND TECHNOLOGY, 2014, 16 : 1649 - 1659
  • [44] Sensitivities of fungal pathogens of pomegranate (Punica granatum L.) to seven different fungicides
    Kc, A. N.
    Vallad, G.
    PHYTOPATHOLOGY, 2015, 105 (11) : 70 - 71
  • [45] The extract from Punica granatum (pomegranate) peel induces apoptosis and impairs metastasis in prostate cancer cells
    Deng, Yuanle
    Li, Yali
    Yang, Fangfang
    Zeng, Anqi
    Yang, Shuping
    Luo, Yi
    Zhang, Yiwen
    Xie, Yongmei
    Ye, Tinghong
    Xia, Yong
    Yin, Wenya
    BIOMEDICINE & PHARMACOTHERAPY, 2017, 93 : 976 - 984
  • [46] Processing of Parboiled Wheat Noodles Fortified with Pulsed Ultrasound Pomegranate (Punica granatum L. var. Malas) Peel Extract
    Milad Kazemi
    Roselina Karim
    Hamed Mirhosseini
    Azizah Abdul Hamid
    Sahar Tamnak
    Food and Bioprocess Technology, 2017, 10 : 379 - 393
  • [47] Characterization of pomegranate (Punica granatum L.) hybrids and their potential use in further breeding
    Yazici, Keziban
    Sahin, Alpaslan
    TURKISH JOURNAL OF AGRICULTURE AND FORESTRY, 2016, 40 (06) : 813 - 824
  • [48] Pomegranate (Punica granatum L.) fruit response to different deficit irrigation conditions
    Mellisho, C. D.
    Egea, I.
    Galindo, A.
    Rodriguez, P.
    Rodriguez, J.
    Conejero, W.
    Romojaro, F.
    Torrecillas, A.
    AGRICULTURAL WATER MANAGEMENT, 2012, 114 : 30 - 36
  • [49] Nano-encapsulation of pomegranate (Punica granatum L.) peel extract and evaluation of its antimicrobial properties on coated chicken meat
    Rahnemoon, Pariya
    Sarabi-Jamab, Mahboobe
    Bostan, Aram
    Mansouri, Elaheh
    FOOD BIOSCIENCE, 2021, 43
  • [50] In Vitro Selection of Cell Lines in Punica granatum L. (Daru) Against Bacterial Blight
    Kumari G.
    Kanwar K.
    Soni M.
    Sharma D.
    Proceedings of the National Academy of Sciences, India Section B: Biological Sciences, 2017, 87 (2) : 591 - 597
12345