Increased Thermostability and Reduced CD4 Affinity of Structure-based Stabilized Prefusion Closed HIV-1 Env Trimer

被引：0
|
作者：
Chuang, Gwo-Yu [1 ]
Geng, Hui [1 ]
Pancera, Marie [1 ]
Acharya, Priyamvada [1 ]
Chambers, Michael [1 ]
Druz, Aliaksandr [1 ]
Tsybovsky, Yaroslav [1 ]
Yang, Yongping [1 ]
Georgiev, Ivelin [1 ,2 ]
Gorman, Jason [1 ]
Joyce, M. Gordon [1 ]
McDermott, Adrian [1 ]
Mascola, John R. [1 ]
Kwong, Peter D. [1 ]
机构：
[1] NIAID, Vaccine Res Ctr, NIH, Rockville, MD USA
[2] Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2016年 / 32卷
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
P19.16
引用
收藏
页码：329 / 329
页数：1
相关论文
共 50 条
  • [21] Targeted infection of HIV-1 Env expressing cells by HIV(CD4/CXCR4) vectors reveals a potential new rationale for HIV-1 mediated down-modulation of CD4
    Zhiping Ye
    George G Harmison
    Jack A Ragheb
    Manfred Schubert
    Retrovirology, 2
  • [22] Crystal Structure of a Cleaved, Stabilized HIV-1 Env Trimer in Complex with a Glycan-Dependent Broadly Neutralizing Antibody at 4.7 Å
    Julien, J.
    Cupo, A.
    Sok, D.
    Stanfield, R. L.
    Lyumkis, D.
    Deller, M. C.
    Burton, D. R.
    Sanders, R. W.
    Moore, J. P.
    Ward, A. B.
    Wilson, I. A.
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2013, 29 (11) : A165 - A166
  • [23] Conformational Engineering of HIV-1 Env Based on Mutational Tolerance in the CD4 and PG16 Bound States
    Heredia, Jeremiah D.
    Park, Jihye
    Choi, Hannah
    Gill, Kevin S.
    Procko, Erik
    JOURNAL OF VIROLOGY, 2019, 93 (11)
  • [24] Development of a Soluble HIV-1 Env Trimer Immunogen Stabilized in the Pre-fusion Closed State from Strain CH505
    Xu, Kai
    Zhou, Tongqing
    Mascola, John R.
    Kwong, Peter D.
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2016, 32 : 98 - 98
  • [25] Structure and Immunogenicity of a Stabilized HIV-1 Envelope Trimer Based on a Group M Consensus Sequence
    Sliepen, Kwinten
    Han, Byung Woo
    Bontjer, Ilja
    Garces, Fernando
    Behrens, Anna-Janina
    Rantalainen, Kimmo
    Brouwer, Philip
    Mooij, Petra
    Schermer, Edith
    van Gils, Marit J.
    Alcami, Jose
    Scarlatti, Gabriella
    Crispin, Max
    Ward, Andrew B.
    Montefiori, David C.
    Moore, John P.
    Shattock, Robin J.
    Bogers, Willy
    Wilson, Ian
    Sanders, Rogier W.
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2018, 34 : 335 - 335
  • [26] Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased env incorporation and viral replication
    Argañaraz, ER
    Schindler, M
    Kirchhoff, F
    Cortes, MJ
    Lama, J
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (36) : 33912 - 33919
  • [27] βTrCP is Required for HIV-1 Vpu Modulation of CD4, GaLV Env, and BST-2/Tetherin
    Song, Yul Eum
    Cyburt, Daniel
    Lucas, Tiffany M.
    Gregory, Devon A.
    Lyddon, Terri D.
    Johnson, Marc C.
    VIRUSES-BASEL, 2018, 10 (10):
  • [28] DC-SIGN Increases the Affinity of HIV-1 Envelope Glycoprotein Interaction with CD4
    Hijazi, Karolin
    Wang, Yufei
    Scala, Carlo
    Jeffs, Simon
    Longstaff, Colin
    Stieh, Daniel
    Haggarty, Beth
    Vanham, Guido
    Schols, Dominique
    Balzarini, Jan
    Jones, Ian M.
    Hoxie, James
    Shattock, Robin
    Kelly, Charles G.
    PLOS ONE, 2011, 6 (12):
  • [29] Publisher Correction: Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody
    Zhi Yang
    Haoqing Wang
    Albert Z. Liu
    Harry B. Gristick
    Pamela J. Bjorkman
    Nature Structural & Molecular Biology, 2020, 27 : 222 - 222
  • [30] Specific binding and contents delivery of liposomes containing CD4 to cells expressing the HIV-1 ENV glycoprotein
    Larsen, C
    Alford, D
    Stevenson, M
    Nicolau, C
    BIOPHYSICAL JOURNAL, 1996, 70 (02) : SU345 - SU345
12345