2-Acetoxyacrylonitrile: use as electrophile equivalent to acetaldehyde in the asymmetric Michael reaction using chiral imines

被引：18

作者：

Keller, L ^{[1
]}

Camara, C ^{[1
]}

Pinheiro, A ^{[1
]}

Dumas, F ^{[1
]}

d'Angelo, J ^{[1
]}

机构：

[1] Univ Paris Sud, Ctr Etud Pharmaceut, UA CNRS, F-92296 Chatenay Malabry, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 03期

关键词：

chiral imines; Michael reactions; 2-acetoxyacrylonitrile; stereocontrol;

D O I：

10.1016/S0040-4039(00)01971-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric Michael addition reaction between a variety of chiral imines and 2-acetoxyacrylonitrile, an electrophile equivalent to acetaldehyde, was reported. The resulting adducts were obtained in fair yields and with de and ee greater than or equal to 95%. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：381 / 383

页数：3

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