2-Acetoxyacrylonitrile: use as electrophile equivalent to acetaldehyde in the asymmetric Michael reaction using chiral imines

被引：18
|
作者：
Keller, L [1 ]
Camara, C [1 ]
Pinheiro, A [1 ]
Dumas, F [1 ]
d'Angelo, J [1 ]
机构：
[1] Univ Paris Sud, Ctr Etud Pharmaceut, UA CNRS, F-92296 Chatenay Malabry, France
来源：
TETRAHEDRON LETTERS | 2001年 / 42卷 / 03期
关键词：
chiral imines; Michael reactions; 2-acetoxyacrylonitrile; stereocontrol;
D O I：
10.1016/S0040-4039(00)01971-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The asymmetric Michael addition reaction between a variety of chiral imines and 2-acetoxyacrylonitrile, an electrophile equivalent to acetaldehyde, was reported. The resulting adducts were obtained in fair yields and with de and ee greater than or equal to 95%. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：381 / 383
页数：3
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